Curative Effect Observation Of DP Regimen In The Treatment Of NSCLC With Different TCM Syndrome Types

Objective: To observe the efficacy of DP regimen in the treatment of non-small cell lung cancer(NSCLC)with different TCM syndromes.Deduce the traditional Chinese medicine attribute and effect of DP scheme,and obtain important clinical data for syndrome differentiation and chemotherapy.Methods: The patients with stage ?b/? NSCLC who were hospitalized in Gansu Cancer Hospital from June 2016 to December 2017 were divided into phlegm and dampness syndrome,blood stasis syndrome,heat toxin syndrome,yin deficiency syndrome and qi deficiency syndrome according to TCM differentiation criteria of lung cancer.There were 30 cases in each syndrome type.All patients were treated with DP regimen(docetaxel + cisplatin)for a period of 3 weeks.Efficacy evaluated after 4 cycles.Results:1.Objective remission rate: The total remission rate was 33.3%.The phlegm and dampness syndrome was 53.3%,heat toxin was 40.0%,blood stasis was 30.0%,yin deficiency was 23.3% and qi deficiency was 20.0%,there were significant differences among five groups(P<0.05).Further pairwise comparison,The difference of remission rate between phlegm and dampness syndrome and qi deficiency syndrome was statistically significant(P<0.01).2.The TCM syndrome improvement rate: There were significant differences among five groups(P<0.05).Further comparison showed that there were significant differences between heat toxin syndrome(90.0%)and qi deficiency syndrome(46.7%)(P < 0.01),heat toxin syndrome(90.0%)and blood stasis syndrome(60.0%)(P<0.01).3.The improvement rate of TCM clinical symptoms(cough,sputum,acute qi):(1)In cough,there was significant difference between heat toxin syndrome(90.0%)and qi deficiency syndrome(53.3%)(P < 0.01).(2)The improvement rate of sputum symptoms:there was significant difference between heat toxin syndrome(86.7%)and qi deficiency syndrome(50.0%)(P<0.01).(3)The improvement rate of Qi acute symptoms: there was significant difference between phlegm-dampness type(86.7%)and Qi deficiency type(43.3%)(P<0.01).4.The side effects of chemotherapy: The incidence of leukopenia in grade ? ~ ? in the five groups was further compared in two groups,there was significant difference between qideficiency type(56.7%)and phlegm dampness type(20.0%)(P < 0.01).The incidence of nausea and vomiting in grade ? ~ ? was further compared between the five groups,there was a significant difference between Yin-deficiency syndrome(46.7%)and phlegm-dampness syndrome(13.3%)(P<0.01).Conclusions: Through this study,we can infer the traditional Chinese medicine attribute and effect of DP scheme,that is,DP scheme is cold and cool,belongs to lung,spleen,kidney meridian,has the effect of clearing heat and detoxifying,dampening and dissipating phlegm,and dispersing knot.It is suitable for NSCLC patients with heat toxin syndrome and phlegm dampness syndrome.