| Objective:To evaluate the clinical efficacy and safety of Qufeng Lianfei recipe in treating cough variant asthma(Fengsheng clonus syndrome)by randomized controlled clinical trial,and to prepare for the further promotion of traditional Chinese medicine in the treatment of cough variant asthma.Methods: A randomized controlled clinical trial was used.Collected in November 2015 to November 2017 in Chengdu,combine traditional Chinese and western medicine hospital outpatient clinic of cough variant asthma(Fengsheng clonus syndrome)patients 90 cases,after informed consent and signed documents were randomly divided into experimental group and control group,45 cases in each group.The control group was given basic treatment of western medicine,and the experimental group was given the basic treatment of western medicine and Qufeng Lianfei recipe.and the treatment time of the two groups was 8 weeks,and follow up half a year.The indexes of VAS,cough degree,LCQ、TCM symptom score,pulmonary function,FeNO,PEF daily mutation rate,liver and kidney function,blood routine and Relapse after six months were observed before and after treatment,and SPSS 19.0 software was used for statistical analysis.Results:1.VAS:After treatment,cough VAS decreased in both groups(7.28 ±1.03 before treatment and 1.40 ±1.12 after treatment in the experimental group,7.68 ±0.93 before treatment and 2.43 ±1.66 m after treatment in the control group,respectively).The difference of VAS between the two groups before and after treatment(5.88 ±1.22 in the experimental group and 5.30 ±1.30 in the control group)was compared with that in the control group.2.The curative effect of cough relief: there were 31 cases of marked effect,11 cases of effective effect,1 case of ineffective,and 98% of total effective rate in the experimental group,21 cases in the control group,19 cases in the effective group,4 cases in the ineffective group.The total effective rate was 91%,the effective rate in the test group was higher than that in the control group,and the Ridit test showed that there was statistical difference between the two groups.3.Evaluation of the quality of cough life: the LCQ scores of the two groups were lower than those before treatment(13.37 ± 3.72 before treatment,5.91±1.87 after treatment).The control group was treated with12.92±3.10 before treatment,and 6.96±1.75 after treatment.After t test,P=0.00<0.01,indicating significant statistical difference;The difference of LCQ scores was compared between the two groups(the difference of the test group was 7.46±3.43,the difference between the control group was 5.83±2.67),and the t test showed that P = 0.03<0.05,indicating a statistical difference.4.TCM symptom score: the scores of TCM symptoms in the two groups were lower than those before treatment(10.17±2.46 before treatment,3.27±2.48 after treatment,10.34 ±2.42 before treatment and 4.34 ±2.56 after treatment in the control group,P<0.01 after t test,indicating that there was significant difference between the two groups.The difference of TCM symptom integral before and after treatment was 6.90±2.49 in the experimental group and 6.02 ±2.46 in the control group,which indicated that there was statistical difference between the two groups by t test(P=0.02<0.05).5.The curative effect of TCM syndromes: clinical control in 1 case,remarkable effect in 21 cases,effective in 20 cases,ineffective in 1case,total effective rate of 98% in the experimental group,while in the control group,there were 0 cases of clinical control,11 cases ofremarkable effect,28 cases of effective and 5 cases of failure.The total effective rate was 89%.The effective rate of the test group was higher than that of the control group.The Ridit test showed that there was statistical difference between the two groups(P=0.01<0.05).6.Lung function,FeNO,PEF mutation rates: two groups of subjects by the treatment of lung function(FEVI/FVC,FEV1,MVV is),FeNO,PEF variation rate was improved,the t test,P < 0.05,statistically significant;Before and after the two groups of treatment,lung function,FeNO and PEF variation rate difference were compared,and P all > 0.05,indicating no statistical difference.7.Safety indicators: After treatment,the blood routine,liver and kidney work were compared before the treatment,and after t test,P was all >0.05,indicating no statistical difference.There were no obvious abnormalities in stool routine,urine routine and electrocardiogram in the two groups during the treatment.There were no adverse reactions and complications in both treatment regimens.8.Relapse: after six months follow-up treatment,experimental group recurrence rate is lower than the control group(treatment group recurrence rate 11.63%,control group recurrence rate 29.55%),by the X2 test,P = 0.04<0.05,statistically significant.Conclusion :Taking the functions of the folding of the lung soup treatment of cough variant asthma(Fengsheng clonus syndrom)in patients with cough,improve TCM symptoms,cough are obvious curative effect on the quality of life and reduce the recurrence rate,and good security,but in improving lung function,reduce FeNO and PEF day showed no significant advantage on the mutation rate. |
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