Clinical Significance Of Combined Detection Of Tumor Markers In Breast Cancer

Background and Objective:The incidence of female breast cancer has been ranked first among the female malignant tumor incidences in China.Furthermore,it has become one of the most common causes of female cancer deaths.Since early breast cancer has no obvious clinical symptoms,the key to reducing the mortality rates and improving the prognosis relies on achievement of early detection,diagnosis and comprehensive treatment.Current medical field utilizes imaging studies as the main approach to diagnosis of breast-related diseases.However,these diagnostic clinical imaging methods also have certain limitations.Tumor markers with their advantages of rapid,simple,non-invasive,inexpensive and continuous monitoring of changes.According to NACB Test Practice Guidelines,TM include CA153?CEA?TPA?TPS?ER?PR?HER-2 and so on.This study aims to explore the significance of the combined detection of different combinations,so as to better guide clinical application strategies.Methods:100 breast cancer patients and 110 patients with benign breast disease,who were diagnosed and treated at the General Surgery Department of the Fourth Central Hospital of Tianjin from January 2014 to January 2017 were selected for the study.And another group of 110 healthy women,who were examined at the same hospital during the same period were selected as the control group for a retrospective analysis.The levels of CA153,CA125,and CEA in peripheral blood were compared and analyzed statistically.Any positive result is considered positive by the combined test.The data obtained in the study was expressed as mean � standard deviation(`x�s).SPSS20.0 software was used for statistical analysis,and t-test was used to compare the data between groups.There is a significant difference when P<0.05.ROC curve and AUC of each indicator were used to further test the efficiency and value for breast cancer diagnosis.Results:1.The levels of serum CA153,CA125 and CEA in the breast cancer group were(35.19�17.02)U/ml,(21.64�12.47)U/ml and(6.90�4.73)ng/ml respectively,which were significantly higher than those in the other two groups.The difference was statistically significant(P<0.05).2.The levels of serum CA153,CA125,and CEA in the benign breast disease group were slightly higher than those in the control group,with no significant difference(P>0.05).3.When a single serum tumor marker was tested,the highest positive rate was CA153 with a sensitivity of 39%;followed by CA125 with a sensitivity of 18%;the lowest positive rate was CEA with a sensitivity of 17%.4.The sensitivities of different combinations of CA153 and CA125,CA153 and CEA,and CA125 and CEA for the diagnosis of breast cancer were 50%,48% and 26% respectively.The combined detection of three serum tumor markers had the highest sensitivity to diagnosis of breast cancer,reaching 56%,and the specificity was lower than that of other tests.5.The AUC of serum CA153,CA125,and CEA for the diagnosis of breast cancer were 0.774,0.750,and 0.700,respectively.The combined detection of AUC for the three items was 0.802,indicationg this combination was the most valuable.Conclusion:1.The three serum tumor markers CA153,CA125 and CEA have certain clinical significance in the diagnosis of breast cancer.2.When a single tumor marker was tested,CA153 was more valuable than the other two.3.Combined detection of three serum tumor markers can improve the early detection rate.4.Combined detection of serum tumor markers can be combined with current clinical imaging tools such as breast B-ultrasound,Molybdenum target,and magnetic resonance to effectively improve the accuracy and sensitivity of early breast cancer diagnosis.