The Study On The Influencing Factors Of Osteoporosis In Inpatients With Schizophrenia

Objective: This study can identify the epidemiological characteristics of inpatients with schizophrenia in our hospital,such as the prevalence of disease,the average level of bone mineral density,gender and age distribution;secondly,in understanding the basic situation of osteoporosis patients with schizophrenia,Through epidemiological investigation to find out the risk factors or protective factors that affect osteoporosis in inpatients with schizophrenia so as to provide evidence for reducing the occurrence of osteoporosis and fractures,saving medical resources and reducing medical disputes.Methods: Select 410 cases of schizophrenia diagnosed adult schizophrenia in our hospital,fill out the questionnaire as required,collect the patient’s age,gender,medication history,medication,medication time,schizophrenia,fill in the PANNS scale and other information.Bone mineral density measurements performed on patients were performed using X-ray absorptiometry.The patients were grouped according to the measured bone density results,namely low bone mass,osteoporosis and normal bone mass.Statistical analysis was performed using SPSS19.0 software.Logistic regression analysis was used to establish a model to determine risk factors and predictive equations.Bone mineral density was used as the dependent variable in the osteoporosis group and the bone mass decrease patient.The investigation factor was used as the independent variable.Multivariate stepwise regression analysis,looking for predictive indicators,and through comparative analysis,eventually determined early predictive indicators.Results: 1.Less than 40 years of age in patients with bone loss and osteoporosis accounted for a total of 20.4%;while those over 40 years of age,osteopenia and osteoporosis accounted for 80.2%.In men,bone loss and osteoporosis together accounted for 36%;female patients with bone loss and osteoporosis accounted for a total of 63.8%..2.In the univariate analysis,the incidence of bone loss was significantly higher in patients >40 years of age than in those aged <40 years(P = 0.001,r = 0.252),and the association between bone mineral density and age was greater.The incidence of bone loss in male patients was significantly lower than in female patients(P = 0.001,r =0.512).The patients with osteopenia and osteoporosis in the medication group were significantly higher than those in the non-medication group(P = 0.001).With the prolonged use of psychiatric patients,the frequency of osteopenia in patients with schizophrenia showed a linear trend of growth,the greater the risk of osteoporosis(male patients P = 0.001;female patients P = 0.000).In male patients,the positive score in the bone reduction group was higher than that in the normal group(P=0.000),the negative score was higher than the normal group(P=0.001),and the general psychopathology score was higher than the normal bone mass group(P= 0.016).The composite score was smaller than the normal bone mass group(P=0.000);in the female patients,the bone mineral reduction group had a higher positive score than the normal bone mass group(P=0.002),and the negative score was higher than the normal bone mass group(P=0.000).In general,the score of psychopathology was higher in the normal bone mass group(P=0.000)and the total score was higher than that in the normal bone mass group(P=0.000),while the composite score was smaller than the normal bone mass group(P=0.000).3.After multivariate regression analysis,the results showed that the schizophrenia medication,drug use,drug age,and composite scale were the main factors affecting bone mineral density(P<0.05),and the mixed drug and drug age were the main factors.The risk factors,the composite scale score is the main protective factor.Conclusion: 1.Age,use of anti-psychotic drugs,medication,medication time is the main factor affecting the decline in bone mineral density in schizophrenia patients.For patients taking long-term medication,and long-term hospitalization patients should be regularly measured bone mineral density,prevention of osteoporosis and fractures.2.Older women are at high risk of bone loss and osteoporotic fractures in patients with schizophrenia.