Clinical Study Of The Effect Of Alendronate Sodium On Bone Mineral Density In Patients With Rheumatoid Disease With Long-term Glucocorticoids

Objective: To evaluate the effect of alendronate sodium tablets on bone mineral density in patients with rheumatoid disease with long-term glucocorticoids.Methods: A total of 50 female patients with rheumatic diseases admitted to our department from January to February 2018,2016 were enrolled.All patients were given oral glucocorticoid for more than 6 months.They were randomly divided into vitamin D+ calcium and vitamin D + calcium.+ Alendronate tablets in two groups,after the corresponding treatment and monitoring of bone metabolism indicators at 0 and 6 months.The differences between the two groups were compared by single factor.The mean values of bone mineral density before and after treatment were compared by t test.P <0.05 was considered statistically significant.Results: Serum calcium and vitamin D in each group did not change significantly before and after treatment(P > 0.1).Bone mineral density measurements were improved in both groups before and after treatment,and bone mineral density increased significantly in the alendronate sodium group(P<0.05).Conclusion: For patients with rheumatic diseases with long-term doses of small doses of hormones,alendronate sodium tablets can effectively improve the bone density of patients,reduce the occurrence of fractures,and play a role in bone protection.