The Effect Of Compound Eosinophil-lactobacillus Tablets On Antibiotic Phase Diarrhea Of Infantile Bacterial Pneumonia

Objective:To observe the clinical efficacy of Compound Eosinophil-Lactobacillus Tablets in the prevention and treatment of antibiotic associated diarrhea(Antibiotic-Associated Diarrhea AAD).To explore the incidence of AAD and the total effective rate after treatment with Compound Eosinophil-Lactobacillus Tablets for children with bacterial pneumonia,so as to provide a theoretical basis for clinical prevention and treatment of AAD.Methods:From October 2016 to October 2017,375 children diagnosed with bacterial pneumonia at the age of 1-3 years of Pediatrics in Affiliated Hospital of Yan'an University were divided into prevention group(n=125),control group(n=126)and observation group(n=124),control group and observation group,according to the random blind method,and the control group and the observation group were treated with antibiotics(according to the condition and drug sensitivity of the children.Results the treatment was supported by sensitive antibiotics),oxygen inhalation,atomization,cough and expectorant.On the basis of the above two groups,the prevention group was given oral Compound Eosinophil-Lactobacillus Tablets(0.5g,warm water oral,3 times / day,and 1-2 hours interval with antibiotics).When the observation group appeared AAD,the oral compound acidophilus milk was given.Bacilli(oral method is same in the same way).Comparing the incidence of AAD between the prevention group and the control group,it is proved that Compound Eosinophil-Lactobacillus Tablets can prevent the occurrence of AAD.The daily stool times,characters,AAD duration,AAD severity and AAD improvement were monitored in the observation group and the control group,which proved that the compound eosinophilic bacilli played an important role in the treatment of AAD Results:1.the incidence of AAD in the prevention group was 19%,the incidence of AAD in the control group was 39%,and the incidence of AAD in the prevention group was P<0.01 compared with that in the control group.2.The total effective rate of the observation group was 73%,while the total effective rate of the control group was 37%.The total effective rate of the observation group was P<0.01 compared with that of the control group.3.After third days of treatment,the number of stool in the observation group was 1.58±0.476 times a day,and the number of stool in the control group was 1.62±0.499 times a day.The daily stool times of the observation group were compared with the control group,P > 0.05,the difference was not statistically significant.The number of stool in the observation group was 5.10±2.253 times a day for fifth days,and the control group was 8.00±1.530 times a day.The daily stool times of the observation group were compared with the control group.P<0.01,the difference was statistically significant;seventh days of treatment,the number of stool in the observation group was 3.27±1.512 times a day,and the number of stool in the control group was 4.31±1.639 times a day.The daily stool times of the observation group were compared with the control group,P<0.01,the difference was statistically significant.4.On the third day of treatment,the daily stool characters of the observation group were 1.83±0.663 points,and the daily stool characters of the control group were 1.98±0.635 points.The daily stool characters of the observation group were compared with the control group,P > 0.05,the difference was not statistically significant.The daily stool characters of the observation group were 1.92±0.577 points and 2.42±0.498 points in the control group,and the daily stool characters in the observation group compared with the control group.P<0.01,the difference was statistically significant;seventh days after treatment,the daily stool characters of the observation group were 1.44±0.580 points,and the daily stool characters of the control group were 1.83±0.630 points.The daily stool traits in the observation group were compared with the control group,P<0.01,the difference was statistically significant.5.The duration of diarrhea in the observation group was 5.52±1.989 days,and the diarrhea duration in the control group was 6.81±1.709 days.The diarrhea duration in the observation group was significantly different from that in the control group(P<0.01).6.The incidence of mild diarrhea in the observation group was 50%,the incidence of general diarrhea was 40%,the incidence of severe diarrhea was 10%,the incidence of mild diarrhea in the control group was 19%,the incidence of general diarrhea was 46%,the incidence of severe diarrhea was 35%.Compared with the two groups of children with mild diarrhea,P<0.01,the difference was statistically significant.Compared with the two groups of children with general diarrhea,P> was 0.05,the difference was not statistically significant..Compared with the two groups of children with severe diarrhea,P<0.01,the difference was statistically significant.Conclusion:1.children in the use of antibiotics and oral administration of Compound Eosinophil-Lactobacillus Tablets can prevent the occurrence of antibiotic associated diarrhea.Therefore,it is suggested that probiotics assist in the clinical use of antibiotics at the same time.2.Compound Eosinophil-Lactobacillus Tablets AAD can significantly reduce children daily stool frequency,stool diarrhea,improve shorten the duration,and to reduce the incidence of severe AAD,so early in the clinical application of probiotics can reduce the side effects of drugs,shorten the course,to avoid serious type of AAD and reduce the pain of patients.