Associations Of Maternal Pre-pregnancy Overweight Or Obesity And Childhood Dietary Intake With Childhood Obesity

Objective: This study was designed to analyze the factors that affected childhood obesity and investigate the association of maternal pre-pregnancy overweight or obesity and childhood dietary intake on childhood obesity,and finally to provide an epidemiological evidence in preventing of childhood obesity.Methods: A prospective cohort study was conducted to included 6195 mother-child pairs which were started from 2012 to 2014 at the Women's and Children's Health Center in Wuhan City,China.Socio-economic characteristics and birth related information were obtained by questioners and chronic disease history before conception and birth outcomes were obtained from medical records.A structured food frequency questionnaire(FFQ)was used to investigate the weekly dietary intake patterns of children at an age of 2 years.Logistic regression model was used to explore the relationship between maternal pre-and pregnancy factors on childhood obesity.The effect of joint exposure of maternal pre-pregnancy overweight or obesity and childhood dietary intake on childhood obesity was evaluated using a multiplicative interaction term between maternal pre-pregnancy overweight or obesity and childhood dietary intake.Results: 1?Among the subjects included in this analysis,the proportion of maternal pre-pregnancy overweight or obesity was 674(10.88%).Of the children,the prevalence of obesity at an age of 2 years was 319(5.14%).2?Results of risk factors associated with childhood obesity indicated that maternal pre-pregnancy overweight or obesity(OR=1.52,95%CI: 1.11-2.08)and macrosomia(OR=1.91,95%CI:1.31-2.79)increased the risk of childhood obesity.3?Although there was no statistically significant between childhood dietary intake and the risk of childhood obesity.Significant elevated ORs in childhood obesity were observed for children with joint exposures of maternal pre-pregnancy overweight or obesity and childhood weekly do not drink sweet drinks(OR=2.19,95%CI:1.30-3.71),intake of sweet drinks above one time(OR=3.99,95%CI:1.59-10.06),and children who intake sweet drinks above one time had a higher risk of childhood obesity.Similarly,childhood weekly do not eat sweet dessert foods(OR=2.12,95%CI:1.10-4.09), intake of sweet dessert foods above one time(OR=2.28,95%CI:1.19-4.38),and children who intake sweet dessert foods above one time had a higher risk of childhood obesity.Conclusions: Maternal pre-pregnancy overweight or obesity increased the risk of childhood obesity.Maternal pre-pregnancy overweight or obesity and childhood dietary intake had a joint effect on childhood obesity.Children combined with a pre-pregnancy overweight or obesity mother and a high-sugar diet in childhood were particularly at a higher risk of emerging childhood obesity.