Correlation Between Serum Vaspin Levels And Blood Pressure In Patients With Preeclampsia

ObjectivePreeclampsia is an idiopathic disease during pregnancy,characterized by hypertension and proteinuria,which could lead to multi-system disorder,and it is a major cause of maternal and perinatal mortality and morbidity.The pathogenesis of preeclampsia is complex and complicated.At present,it is believed that the pathogenesis is related to the damage of vascular endothelium,insulin resistance,placental ischemia and hypoxia,uterine spiral arteries recasting barriers,maternal genetic and environmental factors,and so on.Vaspin,a serine protease inhibitor derived from visceral adipose tissue,is a newly discovered fat factor.Previous studies have shown that vaspin has the effects of improving vascular endothelium damage,improving hypertension,improving insulin resistance,and resisting atherosclerosis.Preeclampsia has common risk factors with cardiovascular disease and metabolic disease,but there is less research on vaspin in preeclampsia and serum.This study investigated the relationship between serum vaspin levels and blood pressure in preeclampsia patients by examining serum vaspin levels in preeclampsia patients.Hoping to provide a new theoretical basis for the prevention and treatment of preeclampsia.Methods1.Research subjects:(1)Preeclampsia group: 62 patients with preeclampsia who were randomly assigned to undergo an examination from May 2015 to July 2017 in the Third Affiliated Hospital of Guangzhou Medical University.(2)Normal group: 60 gestational weeks-matched healthy pregnant women randomly assigned to hospital delivery during the same period were randomly selected.The two groups of pregnant women were excluded from hypertension during pregnancy,chronic hypertension,diabetes,heart disease,liver and kidney disease,patients with polycystic ovary syndrome,immune diseases,infectious diseases,multiple pregnancy and so on.2.Experimental methods: The pregnant women of both groups collected 5 ml of venous venous blood on an empty stomach and centrifuged.The serum vaspin levels were determined by enzyme-linked immunosorbent assay(ELISA).3.Statistical methods: SPSS 23.0 statistical software was used for data analysis.Measured data were showed in mean ± standard deviation.Kolmogorov-Smimov test was used to test whether the variables among the groups met the normal distribution.Levene variance homogeneity test was used to test whether the variance of each group was equal.The non-normal distribution data was analyzed by natural logarithm conversion.Normal distribution data sets were compared using the t-test,and non-normally distributed data sets were compared using the Mann-Whitney U test.Row correlation analysis was analyzed using Pearson or Spearman correlation analysis,P<0.05 as the difference significance criterion.Results1.Serum vaspin levels were 8.83±4.95 ng/mL in the normal group,and the serum vaspin levels were 7.19±4.45ng/ml in the preeclampsia group.2.There was significant difference in serum vaspin between the normal group and the preeclampsia group(P<0.05).The vaspin levels in the preeclampsia group were less than the vaspin levels in the normal control group.3.Correlation analysis showed a significant negative correlation between serum vaspin levels and systolic blood pressure(r =-0.19,P = 0.036),and serum vaspin levels were significantly positively correlated with gestational age and CHOL(r = 0.192,0.306,P = 0.034,0.010).Conclusion1.There is a certain level of vaspin expressed in the serum of normal pregnant women and preeclampsia patients;2.Serum vaspin levels were significantly negatively correlated with systolic blood pressure;3.Serum vaspin levels were positively correlated with gestational age and CHOL;4.The decline of vaspin levels may be an indicator of elevated blood pressure in preeclampsia,and vaspin may be involved in the development of preeclampsia.