| Objective: To observe the clinical effect of yiqi huayu method chanfukang decoction on postpartum placenta accreta,to explore the mechanism and feasibility of treating postpartum placenta accreta,to provide scientific basis for clinical application of postpartum placenta accreta.To provide timely and effective treatment for patients with placenta accreta.Methods: The patients selected from the department of obstetrics and gynecology of Henan Provincial Hospital of Traditional Chinese Medicine(the second affiliated Hospital of Henan University of Traditional Chinese Medicine).72 patients with placenta accreta who met the diagnostic criteria were randomly divided into two groups:experimental group(n = 36)and control group(n = 36).Control group:mifepristone tablets were given orally 25 mg,once every 12 hours for 1 week and 25 mg/d for 1 week at the second week.The control group:yiqi huayu method chanfukang decoction was given orally 2 times a day and 1 bag at a time,and was taken separately in the morning and evening.Color doppler ultrasound and blood?-HCG were examined weekly.The total scores of TCM syndromes,the changes of blood ?-HCG and the maximum diameter of placental accreta tissue were compared between the two groups at 2 and 4 weeks after treatment,the curative effect of the two groups,the time needed for the blood ?-HCG to decrease to normal and the placental tissue to disappear completely were counted within 3 months.Results:1 After three months of observation,the two groups were cured,the effective and ineffective cases were compared(P<0.05),the difference was statistically significant,which indicated that the treatment effect of the observation group was better than that of the control group.2 The total scores of TCM syndromes in the two groups were compared at 2weeks and 4 weeks,and the differences were statistically significant(P<0.05).The time factor:P= 0.000,which indicated that the total score of TCM syndromes in the two groups had statistical difference in their respective time points,and the interaction between time and group was P<0.05,which indicated that the two groups had statistical difference in the trend of time change and showed a downward trend.The decreasing trend of the test group was larger than that of the control group.The results showed that the experimental group was superior to the control group in improving clinical symptoms.3 The decrease of the blood ?-HCG data in the two groups of the 2 and 4 weeks was not statistically significant(P>0.05),and the difference in the treatment for 4weeks was statistically significant(P<0.05).The time factor:P=0.000,which indicated that the blood ?-HCG data of the two groups decreased at their respective time points had statistical difference,and the interaction between time and group was P <0.05,which indicated that the interaction between time and group was P<0.05.There was statistical difference in the time trend between the two groups.The ?-HCG data of the two groups showed a decreasing trend over time.4 The changes of maximum diameter of placenta accreta at 2 and 4 weeks of treatment were compared,and the difference was statistically significant(P<0.05).The time factor:P=0.000,which indicated that there was statistical difference between the two groups in the reduction of the maximum diameter of placenta accreta tissue at their respective time points,and the interaction between time and group was P<0.05,which indicated that there was a statistical difference in the trend of time change between the two groups.The maximum diameter of placenta accreta tissue in both groups showed a decreasing trend with time,and the trend of decrease in the experimental group was larger than that in the control group.5 After three months of observation,the serum ?-HCG data in the test group was significantly shorter than that in the control group(P<0.05).6 After three months of observation,there was no significant difference in the time required for the complete disappearance of placenta accreta between the two groups(P>0.05).7 The incidence of adverse reactions after treatment was compared between the two groups(P < 0.05),and the difference was statistically significant.There was no obvious abnormality in liver and kidney function and blood routine in the experimental group.In the control group,two cases of ALT and / or ALT were slightly higher than the normal value,but all of them were transient.Conclusion:1 Yiqi huayu method chanfukang decoction in the treatment of postpartum placenta accreta,better than mifepristone group;2 Yiqi huayu method chanfukang decoction can obviously improve the postpartum placenta accreta patients' clinical symptoms;3 Yiqi huayu method chanfukang decoction can promote the decrease blood?-HCG data and the excretion,absorption and dissipation of placenta accreta tissue in postpartum placenta accreta patients.4 The adverse reaction of Yiqi huayu method chanfukang decoction in treating postpartum placenta accreta was lower than that in mifepristone group. |
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