| Objective: By observing the changes of the symptoms of the patients,the polymorphonuclear cell count(PMN),the amount of ascites(the deepest water depth of the lower abdomen measured by ultrasonic),white blood cell count,liver function,serum endotoxin(LPS)and serum calcitonin(PCT),the two groups were compared and analyzed to evaluate the clinical efficacy and safety of Modified Ruyi Golden Cream acupoint application combined with western medicine in the treatment of hepatocirrhosis ascites and spontaneous peritonitis.The mechanism of its action was preliminarily discussed.To provide a new idea and method for treating cirrhosis ascites and spontaneous peritonitis.Methods: 60 patients with liver cirrhosis and SBP were selected by prospective randomized controlled study.It was randomly divided into two groups according to the proportion of 1:1,30 in the test group and 30 in the control group.The control group adopted the western medicine routine treatment scheme,and the experimental group was treated with the western medicine routine combined with Modified Ruyi Golden Cream acupoint application.10 days and 1 course of treatment.Then,the newly join the research group,2 days,5days,10 days 4 observation points was studied to record the symptoms and measure ascites polymorphonuclear cells(PMN),the amount of ascites(the deepest water depth of the lower abdomen measured by ultrasonic),white blood cell count,liver function,serum endotoxin(LPS)and serum calcitonin(PCT)in two groups.Change in patient's condition should be detected and recorded at any time.Results: 1.Body temperature recovery time(h)comparison: The body temperature recovery time(h)difference in two groups of patients was statistically significant.The temperature recovery in the experimental group was preceded by the control group(P<0.05).2.Comparison of abdominal pain disappearance time(h):The difference of abdominal pain disappearance time(h)in the two groups was statistically significant,and the effect of the test group was better than that of the control group(P<0.05).3.Comparison of ascites PMN count response cases: two groups of patients after treatment,48 h and 72 h ascites PMN count response cases were not statistically significant(P>0.05).4.The response rate of 48 h and 72 h after treatment was compared:The response rate of 48 h and 72 h in the experimental group was higher than that in the control group,indicating that the test group could rapidly improve the patient's condition(P<0.05).5.The change of ascites amount: After treatment,the ascites amount of the two groups decreased,and the ascites amount of the experimental group decreased more significantly than that of the control group(P<0.05)6.Changes in serum white blood cell count: In the two groups,serum white blood cell count decreased in 5 days and 10 days after entering the treatment group,which was significantly lower in the experimental group than in the control group(P <0.05).7.The comparison of the indexes of PT,ALT and AST after treatment: The PT,ALT and AST indexes of the experimental group were improved after treatment(P<0.05).The indexes of PT,ALT and AST were not improved in the control group(P>0.05).8.The change of serum endotoxin(LPS): The serum levels of LPS in the two groups were improved on the 2 day,the 5 day and the 10 day in the group(P<0.05),and the improvement of serum LPS level in forepart(the 2 day and the 5 day)was more significant than that in the control group(P<0.05).9.Serum procalcitonin(PCT)changes: The serum levels of PCT in the two groups were improved on the 2 day,the 5 day and the 10 day in the group(P<0.05),and the improvement of serum PCT level in forepart(the 2 day and the 5 day)was more significant than that in the control group(P<0.05).10.The integral changes of the symptoms before and after treatment:The two groups were effective in improving the symptoms of fever,abdominal pain and abdominal distension(P<0.05).The two groups were no effective in improving the symptoms of general edema and jaundice(P>0.05).In terms of improving symptoms such as oliguresis,anorexia,fatigue,mental fatigue and lazy speech,the experimental group was effective(P<0.05),while the control group was ineffective(P>0.05).11.Change of total symptom integral:The total symptom scores of the two groups decreased after treatment(P<0.05),and the improvement of the experimental group was more significant than that of the control group(P<0.05).12.Symptomatic efficacy grading evaluation: there was no significant difference in the overall efficacy between the two treatments(P>0.05),and the significant efficiency in the experimental group was higher than that in the control group.Conclusion: 1.Modified Ruyi Golden Cream acupoint application combined with western medicine treatment can significantly shorten the time of body temperature recovery and abdominal pain disappeared in patients with cirrhosis ascites and SBP,significantly improve the response rate of 48 h and 72 h after treatment,and effectively reduce the ascites volume of patients.2.Modified Ruyi Golden Cream acupoint application combined with western medicine treatment can significantly reduce the levels of serum WBC,ALT,AST,PT,LPS and PCT in patients with liver cirrhosis and SBP. |
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