Clinical Study On Treatment Of Ankylosing Spondylitis With Acupoint Injection Of Ozone Water

Objective : To evaluate the efficacy and safety of acupoint injection of ozonated water acupoint injection for 24 weeks of ankylosing spondylitis.Methods: 72 patients with AS were enrolled and divided randomly into ozone water treatment group of 36 cases and drug control group of 36 cases randomly.The ozone water injection site: DaZhui(DU14),bilateral FengChi(GB20),ShenShu(BL23),DaChangShu(BL25),part of JiaJi acupoints(Extra15)and sacroiliac joint space were selected as injection sites and injected20?g/ml medical ozone water into them respectively.The overall dose of ozone water injected was calculated on 1.5ml/Kg,while the proportion of each part of neck,chest,waist and sacroiliac was1:7:4:3.And the treatment for each patient was 1 time per week for 12 weeks,After reaching ASAS20,the treatment was 10 days,and the treatment continued for 12 weeks.Drug control group: Patients were treated with oral Sulfasalazine Enteric-coated Tablets and Celecoxib Capsules.Oral Sulfasalazine Enteric-coated Tablets directions:the first week,0.25 g,Bid;the second week,0.5g,Bid;the third week,0.75 g,Bid;For the remaining 21 weeks,1g,Bid.Oral Celecoxib Capsules directions: 0.2g,Bid,for 12 weeks.Evaluation method and time point: BASDAI,BASFI,BASMI,CRP were evaluated individually before treatment and after treatment for 12,16,18,20 weeks;ASAS20 was used to evaluate the efficacy of ASAS20 after 12 or 24 weeks of treatment;At the same time safety was evaluated before and after treatment.Results: This trial were collected into standard subjects were 72 cases,1 cases of each exfoliated drug group and ozonate group.The drug group dropped out of 1 cases and was followed up by telephone because the subject is on a business trip and fall off.Ozone water treatment groupafter continuous treatment 2 times fall off in 1 case,after the telephone follow-up show that due to the patient going abroad and fall off.The remaining cases are completed on time test,finally to collect 70 cases,ozone water treatment group and drug control group 35 cases each.1.Baseline: There was not statistically significant difference for age and gender between ozone water treatment group and drug control group(P>0.05).BASDAI,BASFI,BASMI and CRP of two groups did not show statistically significant different before treatment(P>0.05).Therefore,it was comparable between two groups.2.Efficacy:After treatment for12,16,18,24 weeks,BASDAI,BASFI,BASMI score and CRP were significantly lower than before treatment in both two groups(P<0.05).BASDAI,BASFI,BASMI score and CRP did not show statistically between After treatment for12 weeks and 24 After treatment for weeks.BASDAI,BASFI,BASMI score and CRP did not show statistically between two groups significant difference after treatment for 12,16,20,24weeks(P>0.05).3.Effect determination: AS patients' ASAS20 remission after twelfth weeks of treatment: the drug control group was 86%,the ozone water group reached 100%,and the ASAS20 remission after twenty-fourth weeks treatment: the drug control group was 80%,the ozone water group reached 95%.4.Safety: 5 patients had moderate untoward effect,but their symptoms were alleviated after treatment and they finish the test on time.The safety level of drug control group: 30 cases in 0grade;5 cases in 2 grade;The safety level of ozone water treatment group: all 35 cases in 0 grade.There was a significant difference between the two groups(P<0.05).Conclusions : 1 ? Medical ozone water can improve clinical symptoms,functionalactivity and improve the quality of life of patients with AS,afety and no toxic side effects.For efficacy and safety,medical ozone water treatment for AS is better than the drug control group.2?Medical ozone water acupoint injection treatment of AS 12 weeks after clinical remission,Changing to 10 days for treatment can ensure the effectiveness and safety,Improving patient compliance,It has the value of clinical promotion.