Study On Relevant Factors In Retransmission Planning Of Nasopharyngeal Carcinoma

Objective:To retrospectively analyze the data of the cases,study the change of body weight,target volume,parotid volume and CT value during the reprogramming of nasopharyngeal carcinoma,and analyze the correlation between the changes and the short-term curative effect and radiation and dry mouth.Provides clinical reference information for radiotherapy for nasopharyngeal carcinoma.Methods:Thirty-six patients with nasopharyngeal carcinoma who were admitted to the Department of Oncology Radiology at the First Affiliated Hospital of Kunming Medical University from October 2016 to December 2017 were recruited.Each patient underwent CT again after 4 weeks of radiotherapy(Computed Tomography,CT).scan line recurrence plan.The changes in body weight,target volume,parotid gland volume,and computed tomography number(CTN)in the reprogrammed plan were analyzed.The age,sex,body mass index(BMI),body weight loss during radiotherapy,and volume change were analyzed.The CTN changes were related to the short-term curative effect and radioresurgery after radiotherapy.SPSS 19.0 was used to analyze the results by paired t-test and Spearman correlation analysis.P value less than 0.05 was statistically significant.Results:1.Compared with the initial weight of radiotherapy,the weight of patients decreased during the radiotherapy cycle.The average weight loss rate was 5.77±3.57%.Among them,17 patients(47.6%)lost more than 5%of their body weight.There were 5 patients(14%)who lost more than 10%of their body weight,and there was a statistically significant difference in the weights of the two plans before and after(t test P<0.01).2.In the replanning plan,the volume of the target area and parotid gland was significantly reduced,and the difference was statistically significant(t test P<0.05).The changes of brain stem and spinal cord volume were not significant,and the difference was not statistically significant(t test P All>0.05).3.The mean CTN of the target area and parotid gland was significantly reduced in the reprogramming plan.The standard deviation of the CTN of the target area and the parotid gland was increased,ie,the distribution was more dispersed and the difference was statistically significant(t test P<0.05).The changes of CTN in stem and spinal cord were not significant,and the difference was not statistically significant(t test P>0.05).4.After 3 months of radiotherapy follow-up,the short-term efficacy results showed complete remission(CR)in 11 cases(30.5%),partial remission(PR)in 21 cases(58.3%),and stable condition(Stabilization of Disease,SD(4)was found in 4 patients(11.2%).The Spearman correlation analysis showed that there was no significant correlation between short-term efficacy after radiotherapy and age,gender,BMI,loss of body weight during radiotherapy,target volume change,and target CTN change.Sex(P values are>0.05).5.Patients with different degrees of radiological xerostomia at the time of replanning were found to have ? degree of dry mouth in 3 cases(8.3%),? degree of dry mouth in 18 cases(50%),and ? degrees of dry mouth in 15 cases(41.7%).No IV dry mouth patients.Using the Spearman correlation analysis,it was found that there was a correlation between volume changes of the left and right parotid glands and radiation-induced xerostomia,which was statistically significant(p = 0.378,P = 0.023 and p = 0.415,P = 0.012).There was no significant correlation between sex,BMI,loss of body weight during radiotherapy,CTN change of parotid gland and radiation and dry mouth(all P>0.05).Conclusion:1.In the replanning plan,the body weight,target volume,parotid gland volume,and CTN were all significantly changed,and the changes were statistically significant.2.There was no significant correlation between the short-term curative effect and the changes in body weight,target volume,and CTN after 3 months of radiotherapy.3.Patients with different degrees of radiological xerostomia at the time of the replanning plan had no significant correlation with the weight of the retransmission schedule and changes in CTN of the parotid gland,but it was found to be related to the volume changes of the right and left parotid glands.