| 1.Professor Liu Ruxiu’s Treatment of Kidney Deficiency Blood Stasis Breast Chest Excavation Based on Data Mining Technology1.1ObjectiveTo discuss Professor Liu Ruxiu’s experience in drug treatment and core prescriptions for the diagnosis and treatment of kidney deficiency and blood stasis,and to summarize his academic features of differentiating and treating kidney deficiency and blood stasis.1.2MethodsIncluding diagnosis and treatment information of 57 patients with kidney deficiency and blood stasis type chest thoracolumbar who were diagnosed and treated by Professor Liu Ruxiu at Guang’anmen Hospital of China Academy of Chinese Medical Sciences from January 1,2016 to June 30,2016,using real-time online display technology(OLAP)and complex network technologies are used for mining analysis,summarizing the laws governing the frequency,type,efficacy,and tropes of clinical prescription drugs,and arranging their clinical cores for the treatment of kidney deficiency and blood stasis,and corresponding Drug addition and subtraction.1.3Results(1)Frequency of Chinese medicine:There are 99 clinical drugs,of which the first 20 are commonly used:Panax ginseng,heterophylla,mulberry,peony,wolfberry;melon glycosides,fleece-flower root,bran fried oyster shell,candied licorice,astragalus,fried almonds,and method.Pinellia,fried Suanzaoren,Rehmannia root,licorice,angelica,salt,psoralen,borage kernel,vinegar kerb,calcined keel.The statistical usage of traditional Chinese medicines is commonly used in clinical practice.In the 20 Chinese herbal medicines commonly used in clinical practice,the use of traditional Chinese medicines account for 60%of the total,and the use of traditional Chinese medicines accounts for 40%,the importance of strengthening.(2)Category of Chinese medicine:The top five types of commonly used drugs are:tonic,hemostatic,qi,diuretic,and phlegm.This shows that Professor Liu’ s treatment of kidney deficiency and blood stasis is the most important application of tonic,while Also use both Qi and blood stasis,phlegm and other drugs.(3)The efficacy of Chinese medicine::The commonly used treatments in the clinic include:Bu Shen San Xue,Yi Qi Sheng Jin,Ning Xin An Shen,Spleen Humidity,etc.,indicating that Professor Liu in the certificate is not confined to a single method,but based on a comprehensive and multi angle of diagnosis and treatment of diseases.(4)Traditional Chinese medicine properties:The first five kinds of commonly used clinical properties are:flat,warm,cold,slightly warm,slightly cold,indicating that Professor Liu’s clinical medication is good at cold temperature and use;commonly used first five kinds of flavor properties are:sweet,bitter,and pungent,bitter and sour,indicating that its prescriptions are mostly based on principles such as Xin Huan Yang,Gan Huayin,Ganbao Qiwei,Kuyi Yin Yin and other theories;in terms of toxicity,toxic,toxic drugs rarely appear,indicating its importance in clinical medication safety.(5)Traditional Chinese Medicine Guijing:Among the prescription drugs,the most commonly occurring first six kinds of medicines are:lung,liver,spleen,kidney,stomach and heart,indicating that Professor Liu Ruxiu believes that kidney deficiency and blood stasis are closely related with the meridians,lungs,liver,spleen,kidney,stomach and heart.(6)Core and clinical addition and subtraction:Prof.Liu’s treatment of kidney deficiency and blood stasis of the chest by the system of Polygonum multiflorum,mulberry,melon,peony root,heterophylla,astragalus,Panax,angelica,Rehmanniae,fried Suanzaoren,salt and bone Fat,Poria,Pinellia ternate,fried bitter almond,bran fried clam shell,candied licorice composition.Clinical addition and subtraction,if the patient has obvious qi stagnation and blood stasis,add fragrant vinegar,vinegar frankincense;obvious spleen and kidney yang deficiency,’plus Codonopsis,Atractylodes macrocephala,Wu Zhuyu,Heishun tablets;liver depression and spleen deficiency,plus Bupleurum,yam.More cough,add Campanulaceae,Zhejiang Fritillaria;shoulders and neck numbness discomfort,add Guizhi,Chuanxiong,Notopterygium.1.4ConclusionProfessor Liu Ruxiu inherited Chinese medicine master Liu Zhiming "on treatment of coronary heart disease from the kidney’s academic thought,she thinks Chest pain is the vacuity syndrome,the deficiency in kidney patients mainly focus on the lack of standard,but blood stasis,phlegm damp evil,clinical treatment should be standard,the real tonic diarrhea tongzhi.Clinically,Professor Liu Ruxiu made good use of Radix Polygoni multiflori,mulberry,Panax pseudoginseng,Radix Astragali,Radix Paeoniae Alba,Radix Astragali and Radix Astragali membranaceus and other drugs.The Kidney-nourishing Hibiscus was used to make Radix Polygoni multiflori,mulberry,and other Ganpin-like relief medicines.Bitter and warm taste of drugs,and in the clinical practice when the proper combination of phlegm,Tong Yang and other drugs to take into account his evil.For the kidney deficiency and blood stasis type chest,Professor Liu Ruxiu treated the main pathogenesis of "Kidney Deficiency and Blood Stasis" and used nourishing kidney and promoting blood circulation(from Radix Polygoni multiflori,mulberry,Gualou,Radix Paeoniae Alba,Radix Paeoniae Radix,Panax Notoginseng,Radix Angelicae Sinensis,Radix Rehmanniae,salt and psoralen and other components)for treatment,with satisfactory results.Treating from the kidney is Professor Liu Ruxiu’s core academic thought in the treatment of coronary heart disease.2.Clinical Observation on Zishen Huogue Prescription in Treating Postoperative Deficiency of Kidney and Blood Stasis Type of Angina Pectoris2.10bjectiveTo investigate the clinical safety and efficacy of Zishen Huoxue Decoction in the treatment of renal collapse and blood stasis angina pectoris after PCI,and to explore its treatment mechanism.2.2MethodsFrom December 2016 to February 2018,60 patients with blood stasis type angina pectoris after PCI in the Department of Cardiology of Guang’anmen Hospital of China Academy of Chinese Medical Sciences were randomly divided into two groups according to 1:1 matching.The control group each 30 cases.The control group was treated according to the basic treatment of western medicine after PCI,and the treatment group was treated with Zishen Huoxue Fang(provided by Guanganmen Hospital Preparation Room)on the basic routine treatment of western medicine.If the patient is accompanied by other types of diseases,such as diabetes,hypertension,etc.,then the corresponding symptomatic routine treatment.The observation period was 1 months,compared before and after treatment,scores of TCM syndromes in patients with Seattle angina scale index of curative effect score,Hamilton anxiety scale,Hamilton Depression Scale score,electrocardiogram,blood lipid level,end point events,at the same time on patients with hematuria during treatment and routine,liver and kidney function and adverse events to observation of monitoring.2.3Statistical analysisThe statistical analysis process was processed by SPSS24.0 software,and the data were statistically analyzed by x + s.If the observed data were in accordance with the normal distribution rule,t test was used;if not,the rank sum test was used.When the counting data are described by frequency,percentage and so on,the chi square test is selected.The test level was statistically significant at P<0.05.2.4Results(1)TCM syndrome:before and after treatment,the total effective rate of the treatment group was 96.66%,and the total effective rate of the control group was 83.33%.Compared with the two groups,the improvement of TCM syndromes in the treatment group was better than that in the control group(P<0.05).The treatment group significantly improved in patients with chest pain,chest tightness,heart palpitations,shortness of breath,waist and knees,dizzy,tongue and pulse condition(P<0.05);there was no significant improvement in tinnitus(P>0.05).The control group in patients with chest pain,chest tightness,heart palpitations,shortness of breath,dizzy has significantly improved(P<0.05);in Yaoxisuanruan,tinnitus,tongue and pulse,no significant improvement(P>0.05).The comparison between two groups,the treatment group curative effect in the chest pain,palpitation,Yaoxisuanruan,tongue and pulse aspects have obvious difference compared with the control(P<0.05);no significant difference in the efficacy of chest tightness,shortness of breath,dizzy and tinnitus(P>0.05).(2)The angina pectoris scale in Seattle:compared w:ith before and after treatment,there was a significant improvement in the degree of physical activity limitation,the frequency of angina pectoris,the stable state of angina pectoris,the subjective feeling and the degree of treatment satisfaction in the treatment group(P<0.05).In the control group,the physical activity limitation,the stable angina pectoris and the frequency of angina pectoris were also significantly improved(P<0.05),but there was no significant improvement in the degree of treatment satisfaction and subjective feelings(P>0.05).The comparison between two groups,the treatment group curative effect in patients with limited physical activity level,treatment satisfaction,angina pectoris attack frequency and subjective feeling aspect has a significant difference compared with the control(P<0.05)in patients with angina pectoris;steady state the degree of improvement,there was no significant difference between the two groups(P>0.05).(3)The Hamilton Anxiety Scale:comparison of before and after treatment,the treatment group in patients with somatic anxiety factor,mental anxiety factor and HAMA score have significant clinical improvement(P<0.05).The control group also had significant clinical improvement in patients’ somatic anxiety factor and HAMA total score(P<0.05),and there was no significant clinical improvement in mental anxiety factor(P>0.05).Comparing the two groups,there was a significant difference between the treatment group and the control group in the effect of physical anxiety factor and HAMA total score(P<0.05),and there was no significant difference in the efficacy of psychotic anxiety factors(P>0.05).(4)Hamilton Depression Scale:comparison of before and after treatment,the treatment group in patients with anesthesia,sleep disorders,diurnal variation,hopelessness,anxiety/somatization and HAMD scores have improved significantly(P<0.05);in patients with weight,cognitive impairment,no significant improvement(P>0.05).The control group had significantly improved in patients’ anxiety/somatization,total score and block of HAMD(P<0.05),but there was no significant effect in day and night change,sleep disorders,weight,cognitive impairment and despair in patients(P>0.05).The comparison between two groups,patients in the group of patients,curative effect and change block,sleep disturbance,hopelessness and the total score of HAMD was significantly different than the control treatment(P<0.05);no significant difference in patients with anxiety/clinical level of somatization,weight and cognitive impairment(P>0.05).(5)ECG:before and after treatment,the clinical effective rate of the treatment group and the control group were 30%and 16.67%,respectively.The effective rate of clinical electrocardiogram was 46.67%and 56.67%,respectively,and the total effective rate of clinical electrocardiogram was 76.67%and 70%respectively.Although it can be seen that the treatment group is better than the control group in the improvement of the ECG,but there is no significant difference between the two(P>0.05).(6)Blood lipid index:compared with before and after treatment,the treatment group had significant improvement in patients’ ApoB,TC,LDL and HDL(P<0.05),but there was no significant improvement in TG and ApoAl(P>0.05).The control group improved significantly in patients’ ApoB,LDL and TC(P<0.05).No significant improvement was found in patients’ HDL,ApoAl and TG level(P>0.05).Comparing the two groups,there was a significant difference in the improvement of serum TC and HDL between the treatment group and the control group(P<0.05).There was no significant difference in the improvement of ApoAl,LDL,ApoB and TG(P>0.05).(7)Inflammation index:Compared before and after treatment,the treatment group improved significantly in CRP and HCY(P<0.05).In the control group,there was also a significant improvement in the CRP level and the level of HCY(P<0.05).Compared with the two groups,the curative effect of the treatment group in CRP and HCY was significantly different than that of the control group(P<0.05).(8)End point events,adverse reactions and safety index:In the clinical study,60 patients observed there was no end point events and adverse reactions,but also in the patients before and after treatment of blood,liver and kidney function of the comparison,there were no obvious abnormal changes(P>0.05).2.5ConclusionStudies have shown that Zishen Huoxue Decoction can provide safe and reliable results for the clinical treatment of renal blood stasis type angina pectoris after PCI.This is reflected in the zishenhuoxuefang can not only improve the clinical symptoms of angina,and improve patients including chest pain,palpitations,Yaoxisuanruan clinical symptoms,improve the lives of patients in anxiety,depression and other negative emotions,so that PCI patients quality of life has been significantly improved;also reflected in zishenhuoxuefang can improve the level of lipid metabolism in patients,reduce the levels of serum inflammatory factors,play a significant role in inhibiting inflammation of atherosclerosis and thrombosis in stent formation etc.Studies have shown that Zishen Huoxue Decoction has no obvious adverse effects on blood routine,liver and kidney function of patients during treatment,and there are no adverse reactions and end points in the study process,indicating that Zishen Huoxue Fang is safe and reliable.Confirmed. |
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