Clinical Effect Of Comprehensive Community Intervention On Patients With Type2 Diabetes Co-morbid Depressive State

Objective:To explore the effect of comprehensive community intervention on glycometabolism,lipid metabolism and depression symptoms of the patients with type 2 diabetes(T2DM)co-morbid depressive state,while providing the integrated control basis for T2DM co-morbid depressive state and clinical thoughts for further study.Methods:60 community T2DM co-morbid depressive state patients(liver-stagnation and spleen-deficiency syndrome)accorded with the inclusive criteria,were selected and randomly assigned to treatment group and control group,30 cases in each group.Both groups received conventional treatment of diabetes and psychological service.The treatment group received comprehensive community intervention additionally,which including diabetes and depressive state education,psychological behavioral intervention,exercise therapy and shuganjieyu capsule based on syndrome differentiation.12 weeks for a course of treatment.The clinical efficiency was evaluated by the level of fasting plasma glucose(FPG)、2h plasma glucose(2hPG)、glycated hemoglobin(HbAlc)、total cholesterol(TC)、triglyceride(TG)、Hamilton Depression Scale-17(HAMD-17)and the 5 factors of HAMD-17.Results:①FPG、2hPG、HbA1c、TC、TG、HAMD-17 score and the 5 factors of HAMD-17 score(anxiety/somatization、body weight、cognitive dysfunction、hysteresis and sleep disorders)of two groups decreased significantly after the treatment(P<0.05,P<0.01).②FPG、2hPG、HbA1c、TC、TG and HAMD-17 score had significantly difference between groups after treatment,and the comparison of difference before and after treatment of the above indexs between groups also had statistical significance.③5 factors score had significantly difference between groups after treatment.④Safety index of two groups had no difference after treatment,all patients had no obvious adverse reactions during the treatment.Conclusions:①Comprehensive community intervention can regulate the glycometabolism and lipid metabolismof patients with T2DM co-morbid depressive state.②Comprehensive community intervention can improve the depression condition of patients with T2DM co-morbid depressive staten.③Comprehensive community intervention on patients with T2DM co-morbid depressive state deserves popularization in community.