The Clinical Study Of Umbilical Therapy In The Prevention And Treatment Of Nausea And Vomiting Caused By Cisplatin

ObjectiveTo observe the clinical efficacy and safety of umbilical therapy combined with tropisetron to prevent and treat nausea and vomiting caused by cisplatin.MethodsA prospective,self-controlled research was conducted in 30 patients who received two consecutive docetaxel and cisplatin chemotherapy.The first course of treatment is umbilical therapy combined with tropisetron,whereas the second course of treatment with tropisetron alone.The operation of umbilical therapy is that the drug was applied to the umbilicus the day before the chemotherapy and change once a day until the end of one cycle of chemotherapy.The indicators included the severity of nausea and vomiting,complete response rate,complete control rate,time to treatment failure,the Karnofsky scores and adverse reactions.Results of all the data uesd SPSS22.0 statistical software for analysis,P<0.05 for a significant difference.Results1.the severity of nausea and vomiting : comparison of the nausea of the two groups,the results showed that in the 5th day and the 6th day the level of nausea in umbilical therapy group was gradually reduced or even disappear,and the incidence of nausea in the control group decreased significantly,rank-sum test showed P<0.05.The grade of vomiting in the umbilical therapy group was less than that of the control group in the fourth to sixth days,rank-sum test showed P<0.05,while the first three days are not statistically significant between the two groups,rank-sum test showed P>0.05.2.complete response rate and complete control rate: In the delay period the whole group of CR was 81.7%(49/60),which the umbilical therapy group was 93.3%,the control group was 70.0%,the difference between the two groups was statistically significant(P < 0.05).During the acute period and entire period,the CR was not statistically significant(P > 0.05).During the acute phase,the delay period and the entire period,the CC of umbilical therapy group was 66.7%,93.3% and 63.3% respectively,while the control group was 60.0%,66.7% and 50.0% respectively.The chi-square test results showed that there were not statistically significant difference between the acute phase and the entire period(P > 0.05),but the difference in the delay period was statistically significant(P<0.05).3.time to treatment failure : The average failure time of umbilical therapy group and control group was 2.3±0.35d?1.7±0.22 d respectively,and log-rank test showed that P<0.05.4.the Karnofsky scores: The difference values of KPS scores in the umbilical therapy group was lower than that of the control group,and the difference was statistically significant(P < 0.05).5.Safety evaluation: none of the patients receiving umbilical therapy were allergic or intolerance,and did not observe the occurrence of adverse events related to umbilical therapy.ConclusionUmbilical therapy reduced the severity of nausea and vomiting caused by cisplatin,improved the CR and the CC in the delay period,prolonged the time of vomiting in the course of chemotherapy and improve the quality of life of patients.It is safe and worthy of clinical promotion.