| ObjectiveApplying a new ultrasonic technique—virtual touch tissue quantification to detect shear wave velocity in patients with chronic kidney disease,and to contrast with the renal biopsy pathology results.The aim of that is to analyze the correlation between VTQ and the degree of renal function damage and pathological types in patients with chronic kidney disease,and to discuss the application value of VTQ in chronic kidney disease.MethodsIn this study,there are two group objects:one including 60 cases of patients with the chronic kidney disease who were hospitalized in Shenzhen Traditional Chinese Medical Hospital from March 1,2016 to February 20,2017,another including 40 cases of health adults for comparison.The ultrasonic instrument was ACUSON S3000 with VTQ technology produced by Siemens of German.The subjects were placed in the prone position or lateral position.Using the conventional two-dimensional ultrasound to exam renal,and to observe the anatomical form and internal structure of the kidney,echo intensity of renal cortex,and to measure the top and bottom diameter and anteroposterior diameter of the kidney.Then the blood flow was observed by color Doppler flow imaging.The maximum blood speed of the kidney artery and the resistance index of the renal interlobar artery were measured by the spectral Doppler.At last,VTQ mode was adopted.Vertical section of right kidney was taken,and keeping scanning position vertical to the sound beam' s direction.The sampling frame was placed in the target area to avoid the renal sinus as far as possible.The subjects were told to hold the breath.Then the velocity values of shear wave were detected.Five samples were taken and the mean was calculated as the results.After elasticity imaging examination,patients with chronic kidney disease underwent renal biopsy in 1—3 days,and the specimens were examined by light microscopy,immunofluorescence and electron microscopy.Resulis1.There was a significant statistical difference(P<0.05)between the VTQ value of the control group and CKD group.The mean value of VTQ in the control group was significantly higher than that of the CKD group.2.According to the pathological result of chronic kidney disease,we depend on the degree of renal damage to compare the value of shear wave velocity,and found that as the degree of renal damage aggravated,the VTQ values of renal parenchyma decreased gradually.There was a negative correlation between the velocity of shear wave and the degree of renal function damage(r=-0.83),the test was statistically significant.3.The shear wave velocity values of the four pathological types which caused glomerular lesions commonly were compared.The results showed that there was no significant difference in the shear wave velocity between the four groups(P>0.05).ConclusionVirtual touch tissue quantification can reflect the changes of tissue elasticity noninvasively,objectively and quantitatively.It provides new ideas and reference index for clinical diagnosis of chronic kidney disease,which has broad application prospects.1.The VTQ value of chronic kidney disease group was less than that of the normal control group.The VTQ technique has clinical significance in the diagnosis of chronic kidney disease.2.There was a negative correlation between the VTQ value and the degree of renal function damage in chronic kidney disease.With the aggravation of renal injury,the VTQ value of renal parenchyma decreased gradually,and the difference was statistically significant.3.Virtual touch tissue quantification has no significant value in the diagnosis of the pathological type of chronic kidney disease,but has a certain degree of correlation with the severity of the disease. |
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