Study On Correlation Between TCM Syndrome Differentiation And Inflammatory Factors And MRI/ADC Value In Acute Cerebral Infarction

ObjectiveThe relationship between the syndrome differentiation,inflammatory factors and the apparent diffusion coefficient of MRI in patients with acute cerebral infarction,and correlation between the syndrome differentiation of ACI and the value of inflammatory factors and MRI/ADC was discussed.At the same time,we analyzed the dynamic changes of serum inflammatory factors and MRI/ADC values after acute cerebral infarction,and explored the role of serum inflammatory factors in the formation of cerebral edema after acute cerebral infarction.It provides a scientific basis for TCM syndrome differentiation in ACI,and takes TNF-alpha,IL-8,IL-10 and ADC values as a series of reference indicators for clinical judgement of patients' severity and prognosis.MethordThe subjects were from April 2017 to February 2018,who received the first diagnosis of acute cerebral infarction,and 240 patients in the Department of encephalopathy of Foshan Chinese Medicine Hospital affiliated to Guangzhou University of Chinese Medicine.The other 30 cases were selected as the control group.The experimental group were divided into wind phlegm fire hyperactivity,wind heat disturbance,phlegm heat,wind phlegm and blood stasis,Qi deficiency and blood stasis,yin deficiency,phlegm Wind God 7.After collecting the basic information of the patients,we extracted the elbow vein blood and separated the serum.The contents of TNF-alpha,IL-6,IL-8 and IL-10 were detected by sandwich enzyme-linked immunosorbent assay(ELISA).The ADC value was detected by parallel MRI scan.Observation: the frequency distribution of ACI and TCM syndrome type;the ACI TCM syndrome distribution characteristics of onset age and gender stratification based on the distribution of lesions in ACI patients;the incidence features and advantages of ACI syndromes(OR);the ratio of ACI TCM syndrome type of serum inflammatory factor TNF-alpha,IL-6,IL-8,IL-10,ILcorrelation analysis;correlation analysis and stroke syndromes of the patients with ACI value of MRI/ADC;the correlation analysis of serum inflammatory factor ACI and MRI/ADC value;Results(1)The age of all cases was 35-85 years old,of which 35-45 age group accounted for 8.1%,46-55 age group accounted for 23.3%,56-65 age group accounted for 22.2%,66-75 age group accounted for 28.5%,76-85 age group accounted for 17.8%.(2)The frequency of occurrence of all the syndromes(incidence)from high to low is: wind phlegm,wind phlegm fire hyperactivity,blood stasis,phlegm heat,Yin wind and wind heat disturbance,phlegm wet god.(3)The distribution of lesions in Qi deficiency and blood stasis syndrome and wind,phlegm and blood stasis syndrome is mainly in the distribution of corona radiata and basal ganglia.The syndrome of qi deficiency and blood stasis is common in radiological crown lesions,while the lesion of wind and phlegm obstructing collaterals is more common in basal ganglia region,andthe lesions occurred mainly in the basal ganglia and brain,internal organs are more concentrated in the basal ganglia and brainstem.(4)The cerebral infarction group compared with control group,ADC decreased significantly,and between different TCM Syndromes of acute ischemic stroke ADC value had no significant difference(5)The normal group compared with the ACI group,TNF-6,IL-8,alpha IL-levels were significantly increased,while the level of IL-10 decreased,with a significant difference(6)The different TCM syndromes in patients of TNF-alpha and IL-6 level difference,the wind heat disturbance group and phlegm between God group showed no significant difference,but the two was significantly higher than that of the other five groups,22 had significant difference compared between the remaining groups.And the other five groups: TNF-alpha and IL-6 levels from high to low are: wind phlegm heat type,phlegm heat type,solid type,yin deficiency and wind type,Qi deficiency and blood stasis type,wind phlegm stasis type.(7)The difference to cerebral infarction patients with different syndromes of IL-8 levels,including wind heat disturbance group and phlegm between God group showed no significant difference,but the two was significantly higher than that of wind phlegm heat,phlegm heat,yin deficiency,Qi deficiency and blood stasis,wind phlegm and blood stasis of other between the five groups,phlegm heat and blood stasis group there was no significant difference between the 22 groups had significant difference compared between surplus.(8)The difference between the group of cerebral infarction patients with different syndromes IL-10 levels: the fire disturbance group and phlegm between God group showed no significant difference,but the two was significantly lower than that of the other five groups,the wind phlegm fire and phlegm dampness Kang God between groups have no significant difference,wind phlegm and hyperactivity of fire hot on the disturbance between the groups was no significant difference between,phlegm heat and blood stasis group there was no significant difference between the 22 groups had significant difference compared between surplus.Conclusion1.The traditional four consultations are easily affected by human factors,and lack of objective and quantifiable quantitative indicators.2.The levels of inflammatory cytokines in peripheral blood of patients with acute ACI were significantly higher than those in normal subjects,indicating that inflammatory responses play a key role in the pathological process of cerebral infarction and may be used as one of the indicators of the severity of acute cerebral infarction patients.3.The levels of positive inflammatory cytokines TNF-?,IL-6,and IL-8 in the experimental group were always in the top three positions,namely,wind phlegm type and phlegm type,indicating TNF-?,IL-6,IL-8 in the two high expression,is likely to be the traditional identification of different types of identification in the wind and fire type,and phlegm fever type and other five types of reference indicators.4.In the experimental group,the level of negative inflammatory cytokines IL-8 was low,and the other three syndromes that were the lowest were other syndromes(wind and fire disturbances combined with dampness and monsoon),wind and heat,and fever.The type of burdock,which is basically consistent with the results of positive inflammatory factors,shows that IL-10 is likely to become a reference indicator for traditional syndrome differentiation.5.The value of modern test and imaging parameters on classification was found through research: Infarct location,ADC values,and inflammatory factors TNF-?,IL-6,IL-8,IL-10 in the cranial MRI manifestations of acute cerebral infarction.There is a certain correlation with TCM syndrome differentiation6.The diagnostic content and inflammatory factors of acute cerebral infarction can be used as a microscopic and quantitative indicator of clinical syndrome differentiation in TCM,thus providing an important reference basis for ACI TCM syndrome differentiation,and making up for the lack of dialectical analysis through the traditional four diagnostic abstracts,increasing the dialectical Chinese medicine Accuracy provides a more accurate basis for Chinese medicine treatment.