The Study On TCM Syndromes Of Type 2 Diabetes Mellitus Complicated With Cerebral Infarction And Its Correlation With ABCA1

ObjectiveIn order to explore the correlation between ABCA1 and cerebral infarction in type 2 diabetes mellitus,the indexes of glucose and lipid metabolism,carotid atherosclerotic plaque ABCA1 and TCM syndromes were studied.It provides a feasible predictor for the patients with type 2 diabetes mellitus complicated with cerebral infarction and provides the basis and direction for the prevention and treatment of type 2 diabetes mellitus cerebrovascular disease by the combination of Chinese and western medicine.MethodsCollected the patients admitted by the second people's hospital of shenzhen nerve internal medicine and endocrinology during September 2016 to October 2017,including 30 cases of patients with type 2 diabetes(group DA),30 patients with type 2 diabetes complicated with cerebral infarction(group DB),30 cases of patients with cerebral infarction(group DN).Collect the general data of the patients,and four diagnostic data of Chinese medicine.Detect the biochemical indexes of the patients by collect blood through the fasting vein,and do the color Doppler examination of the cervical artery.The serum ABCA1 level of all the patients was detected by Elisa.Finally,the software was used to analyze the blood sugar,blood lipid,carotid atherosclerotic plaque,ABCA1 level,and the characteristics of TCM syndrome type of patients with type 2 diabetes combined with cerebral infarction and the correlation with ABCA1.Results1.Comparison of FPG?2hPG?HbA1c:the level of HbA1c in the group DB was significantly higher than that in the group DA and group DN(P<0.01),and the difference was statistically significant(P<0.01).Comparison of LDL-C:the level of group DB was higher than DN group(P<0.01).2.The comparison of ABCA1:when compared with DA group,the level of ABCA1in group B was lower than that in group DA,the difference was significant statistically(P<0.01),and the concentration of ABCA1 in group B was higher than that in group DB(P<0.01).3.Compared with DA group,the unstable plaques in DB group increased significantly(P<0.05),while there was no significant difference(P>0.05)in DN group,and there was a significant difference(P<0.01)in unstable plaques in DN group compared with that in DB group(P<0.01).4.The correlation between ABCA1 and all the observed indexes:the level of ABCA1 was negatively correlated with HbA1c?2 hPGN(P<0.01,P<0.01,P<0.05),but had no significant correlation with other indexes(P>0.05).5.The syndrome differentiation analysis of DB group showed that Qi and Yin deficiency combined with blood stasis syndrome was the main TCM syndrome type in DB group,accounting for 60.00%,the difference was statistically significant(df=2,X~2=12.800,P=0.002<O.01).Conclusion1.Poor control of blood glucose and substandard low density lipoprotein concentration are important influencing factors for cerebral infarction in type 2 diabetes mellitus.2.Patients with type 2 diabetes mellitus complicated with cerebral infarction and simple type 2 diabetes group had certain cholesterol reversal transport disorders.3.Plaque instability may lead to cerebral infarction in patients with type2 diabetes mellitus and may be related to plaque instability.4.The expression of ABCA1 may be related to the fluctuation of blood glucose,but there is no significant correlation between ABCA1 and plaque stability in patients with type 2 diabetes mellitus.5.Type 2 diabetes mellitus complicated with cerebral infarction is characterized by Qi and Yin deficiency with blood stasis.In the treatment of traditional Chinese medicine,attention should be paid to invigorating qi,nourishing yin and activating blood circulation.