| ?Background and purpose? With the progress of the development of medical technology in recent years,thanks to the diversity of screening methods for lung cancer and the improvement of treatment means,the early detection rate of lung cancer has been greatly improved from 10 years ago.However,the incidence and mortality of lung cancer still occupy the first place in the malignant tumor.One of the main reasons is the lack of sensitive indicators for early monitoring of lung cancer patients' condition.In recent years,a large number of studies have found that 5%-15% lung cancer patients are accompanied by thrombocytosis,and this means the important clinical significance to the hypercoagulability of lung cancer patients and the metastasis' promoting of lung cancer.So evaluate the number,shape and function of platelets in different stages of non-small cell lung cancer and the difference of corresponding indices in different stages of non-small cell lung cancer under different tobacco exposure conditions,and then research the relationship between the quantity,shape and function of platelets and coagulation and fibrinolytic function.Depend on the results,we expect to guide the staging and prognosis of lung cancer patients.?Methods? 1?A retrospective analysis of 67 patients with primary non-small cell lung cancer from January 2016 to January 2017 in Department of respiration of Qingdao municipal hospital was conducted.A total of 33 patients were randomly divided into 33 cases in the early stage(I / II)of non-small cell lung cancer(I / II),which including 19 males,14 females,were 54 years to 88 years old,with an average age of(68.82 ± 1.61)years;A total of 34 patients with advanced non-small cell lung cancer(Group III / IV),including 16 males and 18 females,were 52 years to 87 years old,with an average age of(69.23 ± 1.69)years.Among the early non-small cell lung cancer patients(I / II),there were 14 smokers and 19 non-smokers,and there were 16 smokers and 18 non-smokers of non-small cell lung cancer(III / IV).2?The number of thrombocytopenia(PLT),average platelet volume(MPV),platelet pressure product(PCT),platelet distribution width(PDW)and corresponding platelet aggregation(MA value in thrombus map),fibrous eggs,and fibrous eggs were included in the retrospective study.The white capacity(K value in thrombus elasto graph),prothrombin time(PT),activated partial thromboplastin time(APTT)and D-Di were quantified.3?After the end of the statistics,the differences between the two groups were compared and their clinical significance was analyzed.?Results? 1?The patients were all primary treatment cases and the patients' data were all completed.There was no statistical difference between the patients' pathological type,sex,smoking exposure and age factors(p> 0.05).2?The early group patients' PLT was(217.73 ± 49.92)*10^9/L,and the advanced patients' PLT was(255.91 ± 86.91)*10^9/L,there was difference between the two groups(p < 0.05);The MPV value of the early group was(9.97 ± 0.89)fl,and the MPV value of the advanced group was(9.45 ± 0.76)fl,and the results of the two groups were different(p < 0.05);In the early group,PDW was(11.48 ± 1.76)fl,while PDW in the advanced group was(10.40 ± 1.44)fl,and there was difference in the two groups(p < 0.05).;In the early group,MA(61.22 ± 4.2)and MA in the advanced group were(64.24 ± 6.49),and there was difference in the index between the two groups(p < 0.05);There was no difference in index between the two groups(p > 0.05).3?The early group patients' number of platelets(PLT)[(243.85 ± 43.80),(243.85 ± 43.80)*10^9/L],average platelet volume(MPV)[(9.52 ± 0.66)(10.28 ± 0.84)]fl,platelet specific volume(PCT)[(10.59 ± 1.41),(12.12 ± 1.59)]% between the smoking and non-smoking patients was proved different(p < 0.05);The ratio of platelet specific volume(PCT)[(0.23 ± 0.03),(0.20 ± 0.05)]%,platelet aggregation(MA)[(60.95 ± 5.04),(60.98 ± 3.89)] in the two groups was no difference(p > 0.05);In patients with stage III / IV non-small cell lung cancer,there was difference in the number of platelets(PLT)and platelet aggregation between the smokers and the non-smoking patients(p < 0.05).;The average platelet volume(MPV)and the mean platelet specific volume(PCT)in the two groups were not different(p > 0.05).4?Compared with stage I / II of non-small cell lung cancer patients,there was no difference between PT(S)and D-Di polymer in the prothrombin time(p > 0.05);and the comparison of activated partial thromboplastin time APTT(S)showed that there was difference between the two groups(p < 0.05).In patients with stage I / II non-small cell lung cancer,there was no statistically significant difference in coagulation function,fibrin,prothrombin time PT(S),activated partial thromboplastin time APTT(S),and D-Di aggregation(p > 0.05);In patients with stage III / IV non-small cell lung cancer,there were statistically significant differences in coagulation function,fibrin,activated partial thromboplastin time APTT(S)and D-Di aggregation(p < 0.05),while the comparison of PT(S)in prothrombin time indicated that the two groups were statistically different(p > 0.05).5?The platelet aggregation ability MA was associated with the number of platelets and the level of fibrinogen(K).The regression model was obtained by multivariate linear regression analysis: MA=50.941±0.046*PLT±0.48*K.?Conclusion? 1.The longer the staging of non-small cell lung cancer,the stronger platelet aggregation and adhesion ability,and abnormal platelet morphology.2.The number and aggregation of platelets in smoking group were higher than those in non-smoking group. |
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