| ObjectiveFunction images of medication-overuse headache(MOH)patients were obtained to detect altered brain regions and explain the potential pathogenesis based on the regional homogeneity analysis of the resting-state functional magnetic resonance imaging,which may provide a new direction for the treatment of MOH.Methods1.All data of outpatients with MOH admitted to Chinese PLA general hospital and the first affiliated hospital of Chinese PLA from May 2016 to October 2017 were collected,which include personal information,the characteristics of headache and the information of medication overuse;2.Healthy controls matching by age and gender with MOH patients were recruited;3.All participants received the resting-state functional magnetic resonance imaging scanning and regional homogeneity analysis was used to compare the brain function of two groups.Results1.16 MOH patients and 16 healthy controls were enrolled with 14 women and 2 men in each group;2.Altered regional homogeneity was detected in the pons,periaqueductal gray,anterior cingulate gyrus,left cerebellum,right cerebellum,occipital lobe,orbitofrontal cortex,parahippocampal gyrus,lentiform nucleus,precuneus and posterior cingulate gyrus among patients and healthy controls.ConclusionIn the resting state,MOH patients had altered brain function which related to pain processing or substance addiction during the ictal period. |
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