| Objective: This study aims to investigate the influence of fluoride exposure on implant osseointegration.Methods: A total of 24 male New Zealand rabbits were randomly divided into the control group and the fluoride exposure group,with 12 rabbits in each group.Rabbits in the control group and fluoride exposure group were fed with tap water and 200 mg/L sodium fluoride(Na F)solution,respectively.After 2-month feeding,two tapered titanium implants were inserted into the extraction socket immediately after extraction of rabbit mandibular anterior teeth.Four rabbits in each group were sacrificed to collect the mandible samples with implants at 1,2 and 3 months postimplantation,respectively.The imageological and histomorphometry examinations were performed to evaluate the implant osseointegration.Results: The bone volume around the implants increased in groups.The bone mineral density(BMD)in fluoride exposure group was significantly lower than that of control group after implantation for 2 months and 3 months according to the Micro-CT data.The bone-implant contact ratio(BIC)in fluoride exposure group was much lower than that of control group at 3 months after implantation according to histomorphometry exaimination.Conclusions: Fluoride exposure affected the quality of bone surrounding the implant and significantly reduced the BIC of implants in the late stage of bone integration. |
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