| Objective:To investigate the prevalence of dry eye and the ocular surface of patients with different degrees of myopia and the ocular surface by Keratograph 5M,and to understand the ocular surface function changes in patients with different levels of myopia.Methods:Prospective case-control study.Select 160 patients(320 eyes)who were diagnosed with myopia in Hunan Provincial People’s Hospital between July 2016 and February 2018 were selected as the case group,at the same time,52 non-refractive volunteers(104 eyes)were randomly selected as the control group.The 212 patients were divided into four groups according to the degree of nearsightedness:the group of the positive group(52 cases),mild(55 cases),moderate(54 cases),and high-degree(51 cases)myopia groups.All patients underwent routine ophthalmologic examination and ocular surface function analysis,and tear meniscus height(TMH),break up time(NIBUTf and NIBUTav),lipid layer and meibomian gland grade and conjunctival hyperemia,and cornel fluorescein staining(CFS).Statistical analysis was used to compare the ocular surface function of the four groups.Result:(1)Prevalence of dry eye:As the degree of myopia increases,the prevalence of dry eye in patients with different degrees of myopia gradually increases.The prevalence of dry eye in the face group 27.88%,the prevalence of dry eyes in the mild,moderate,and high-degree groups 29.09%,41.67%,and 48.04%,there was a difference in the prevalence of dry eye between the four groups(P<0.01);the four groups are compared in pairs,there was a significant difference in the prevalence of dry eye in the group of moderate,mild myopia and middle and high myopia(P<0.01).(2)Tear meniscus height:The TMH of the normal and mild,moderate,and high myopia groups were all within the normal range(TMH>0.20 mm),there was no significant difference between the four groups(P>0.05).(3)Break up time:Compared the group,tear break up time(first)and tear break up time(average)were significantly decreased in different myopic eyes,and the degree of myopia was increased,NIBUTfand NIBUTav shortened significantly,there was a statistically significant difference between the four groups(P<0.01).(4)Lipid layer and meibomian gland grading:Compared the group,as the degree of myopia increased,the thickness of lipid layer became thinner and the proportion of meibomian glands in patients with different degrees of myopia increased,the difference was statistically significant(P<0.05);there was a statistically significant difference between the myopic group and the mild and moderate myopia group(P<0.05).(5)Conjunctival hyperemia and cornet fluorescein staining Compared the group,the conjunctival hyperemia and corneal fluorescein scores in the moderate and high myopia group were increased,and the difference was statistically significant(P<0.05),after comparison between the two groups,there was no significant difference in conjunctival hyperemia and comeal fluorescein scores between face group and mild myopia group(P>0.05).Conclusions:1.The Keratograph 5M new ocular surface analyzer can objectively and accurately evaluate the ocular surface and tear film of patients with different degrees of myopia.There are differences in the prevalence and severity of dry eye in patients with different degrees of myopia.2.With increasing degree of myopia,the impairment of ocular surface function in patients with different degrees of myopia increased,mainly in:tear film instability,lipid layer thinning,the lack of meibomian gland,ocular surface inflammation. |
