| PurposeTo observe the clinical effect of Qingwei Jiangni Recipe on patients with liver-stomach type of heat reflux esophagitis and its effect on serum MTL,and to explore the mechanism of Qingwei Jiangni Decoction.MethodSeventy patients were selected and divided into two groups randomly,35 cases in each group.The treatment group was given Qing wei Jiang ni Fang decoction orally,the control group was given oral rabeprazole and domperidone,were discontinued during the treatment of other drugs,the treatment cycle was 8 weeks,recording the two groups of patients before and after treatment of TCM clinical syndromes points,Quality of life scores,esophageal mucosal grading and integral and serum MTL values,and after treatment,two groups of patients with clinically cured and markedly effective were screened and patients' RDQ scores were recorded.The patients were followed up every4 weeks for 12 weeks,each time The patient's RDQ score was recorded.After the test,the collected data were analyzed.Results(1)The clinical efficacy of traditional Chinese medicine: 15 cases were cured in the treatment group,markedly effective in 10 cases,effective in 6 cases,ineffective in 4cases,effective rate was 88.57% in the control group,11 cases were cured,8 cases markedly effective in 6 cases,The effective rate was 71.43%,the effective rate of comparison,the two groups,the treatment group was better than the control group,the difference was statistically significant(P<0.05);after treatment,the TCM symptom score was 4.26±5.69 in the control group and 7.69±8.10 in the control group Compared with the control group,the difference between the two groups was statistically significant(P <0.05).(2)Gastroscopy comparison: The treatment group before treatment,the score was2.29±0.89,1.09±0.85 after treatment,the control group before treatment score2.31±0.90,after treatment,the score was 1.14±1.03,the two groups within the comparison,the difference was(P<0.05).There was no significant difference between the two groups after treatment(P>0.05).After treatment,the treatment group recovered in 9 cases,markedly effective in 7 cases,effective in 15 cases and ineffective in 4 cases,the effective rate was 88.57% In the control group,10 cases were cured,6 cases markedly effective,14 effective and 5 ineffective.The effective rate was 85.71%.There was no significant difference between the two groups(P>0.05).(3)Comparison of quality of life: before treatment,the quality of life of the treatment group was 15.80±4.38,the score after treatment was 2.66±1.55,the control group before treatment was 16.29±4.79,after treatment was 6.31±2.17,There was no significant difference between the two groups(P>0.05),the difference between the two groups was statistically significant(P<0.05),after treatment,the two groups were better than the control group,the difference was statistically significant(P<0.05).(4)Comparison of serum MTL: MTL level before treatment was 203.97±17.25,MTL level after treatment was 286.86±26.00,MTL level before treatment was 200.14±16.92,after treatment was 246.71±22.14,both groups before treatment There was no significant difference between the two groups(P>0.05).The difference between the two groups was statistically significant(P<0.05).After treatment,the two groups were higher than the control group,the difference was statistically significant(P<0.05).(5)long-term efficacy comparison: The treatment group recovered,markedly effective in a total of 25 cases,6 cases of recurrence during the follow-up,the recurrence rate was24.00%;control group cured,markedly effective cases were 19 cases,11 cases of recurrence during follow-The recurrence rate was 57.89%.The two groups,the treatment group recurrence rate was significantly lower than the control group,the difference was statistically significant(P<0.05). |
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