Yiqi Huoxue Method Of 60 Patients With AECOPD Blood Stasis Syndrome Clinical Curative Effect Observation And Mechanism Of Action

Objective:To collect cases of AECOPD,and to observe the clinical efficacy of yiqi huoxue in treating patients with AECOPD,and to provide a scientific basis for its clinical application.Research on CRP and IL-17,SAA and correlation between the severity of AECOPD patients of blood stasis syndrome,from the perspective of systemic inflammatory response to explore and its possible mechanism of yiqi huoxue method in the treatment of AECOPD.Methods:According to the GOLD guide（2013）and guide（2011 edition）of COPD in TCM diagnosis and treatment,select clear diagnosis of AECOPD,December 2016-January2018 in the First Affiliated Hospital of Anhui university cadres respiratory medicine hospital,60 patients with syndrome of blood stasis;According to the random number table method,divided into 2 groups,30 cases in each group.The control group was named as the control group and the treatment group,and the control group was treated withroutinetreatment,includingoxygentherapy,anti-infectionand anti-inflammation,anticonvulsiveasthma,relievingcoughandphlegm,nutritional support,and correcting electrolyte disorder,etc.Treatment group on the basis of routine therapy plus qi and reasons,namely the conventional treatment combined with Shengmai injection 60mL in 5%glucose injection 100mL 30mg intravenous drip and Danhong injection in 5%glucose injection 100mL intravenous drip;Both groups were treated 1 times a day,and the duration of treatment was 10 days.60 patients were admitted to the hospital on the day of admission without oxygen,and 2 ml of arterial blood was extracted for blood gas analysis to record the values of PaO₂ and PaCO₂.Makes extraction of venous blood in the morning next day 2ml CRP,venous blood 4ml（2mlx 2tube）let stand 4℃after 2h,3000r/min state centrifuge for 10min,further clear fluid collection,and transfer and packaging in EP tube,placed in-80℃refrigerator frozen under test,after waiting for specimen collection complete using ELISA method to detect the contents of IL-17,SAA;After 10 days of treatment,2ml of venous blood was extracted again for CRP,IL-17,SAA,specimen collection and detection methods.Blood gas analysis（2ml）was performed on day 10.After finishing the data collection and finishing,the IBM SPSS Statistics 22.0 software was used for statistical analysis.Results:1.The symptoms integral of the treatment group and the control group were 11.200±2.310 and 11.800±1.955 points,and the discrepancy was not statistically significant（P>0.05）.compared with that of the two groups.Treatment group and control group after treatment in patients with symptoms integral were 3.700±1.822 and 5.900±1.936points,it has the obvious changes（P<0.01）,two groups of treatment is effective,the treatment group than the control group after treatment symptoms integral improvement is more apparent,the discrepancy is statistically significant（P<0.01）.The clinical control group of the treatment group was 5 persons,15 people were effective,10 were valid and 0 were invalid.In the control group,1 person was controlled,8 were effective,19 were valid and 2 were invalid.The effective discrepancy between the two groups（P<0.05）was statistically significant,indicating that the treatment group was better than the control group.2.Before treatment,there was no statistically significant discrepancy between the treatment group and the control group about CRP（P>0.05）.There was a statistical discrepancy in the treatment group before and after treatment（P<0.01）,and there was a statistical discrepancy in the control group before and after treatment（P<0.01）.There was no statistical discrepancy between the two groups after treatment（P>0.05）.3.Before treatment,there was no statistically significant discrepancy between the treatment group and the control group about IL-17（P>0.05）.There was a statistical discrepancy in the treatment group before and after treatment（P<0.01）,and there was a statistical discrepancy in the control group before and after treatment（P<0.01）.After treatment,the treatment group decreased IL-17 better than the control group,and the discrepancy was statistically significant（P<0.01）.4.Before treatment,there was no statistically significant discrepancy between the treatment group and the control group about SAA（P>0.05）.There was a statistical discrepancy in the treatment group before and after treatment（P<0.01）,and there was a statistical discrepancy in the control group before and after treatment（P<0.01）.After treatment,the treatment group decreased SAA better than the control group,and the discrepancy was statistically significant（P<0.01）.5.Before treatment,there was no statistically significant discrepancy between the treatment group and control group about PaO₂ and PaCO₂（P>0.05）.PaO₂:the discrepancy between the treatment group and the control group was statistically significant（P<0.01）.After treatment,the increase of PaO₂ in the treatment group was higherthanthatinthecontrolgroup,andthediscrepancywas significant（P<0.01）.PaCO₂:the discrepancy between the treatment group and the control group was statistically significant（P<0.01）.Compared with PaCO₂ in the treatment group and the control group,the discrepancy was not statistically significant（P>0.05）.6.Before treatment CRP and negatively correlated with PaO₂,correlation coefficient r=0.798,show the significant correlation（P<0.01）,and PaCO₂ show significant positive correlation,the correlation coefficient of r=0.746,P<0.01),and symptom score were positively correlated,the correlation coefficient of r=0.803（P<0.01）;Before treatment IL-17 negatively related with PaO₂,correlation coefficient r=0.779,show the significant correlation（P<0.01）,and PaCO₂ show significant positive correlation,the correlation coefficient of r=0.756,P<0.01),and symptom score were positively correlated,the correlation coefficient of r=0.724（P<0.01）;Before treatment SAA are negatively related with PaO₂,correlation coefficient r=0.779,show the significant correlation（P<0.01）,and PaCO₂ show significant positive correlation,the correlation coefficient of r=0.540,P<0.01),and symptom score were positively correlated,the correlation coefficient of r=0.560（P<0.01）.7.Before treatment CRP and IL-17 were positively related,the correlation coefficient of r=0.704,show the significant correlation（P<0.01）,the relationship between CRP and SAA were positively correlated before treatment,the correlation coefficient of r=0.650,show the significant correlation（P<0.01）,Before treatment IL-17 and SAA were positively related,the correlation coefficient of r=0.516,show the significant correlation（P<0.01）.Conclusions:1.The beneficial air and blood circulation method can reduce the IL-17 and SAA indicators in patients with AECOPD,and the CRP index is not significantly reduced,and the overall efficacy of the treatment group is better than that of the control group.2.The changes of CRP,IL-17 and SAA were negatively correlated with PaO₂,positive correlation with PaCO₂,and symptom integration.There was positive correlation betweenCRP andIL-17,CRP andSAA,IL-17andSAA.Clinically,itcan comprehensively judge the efficacy and the patient’s condition.3.The accurate AECOPD patients can be treated by yiqihuoxue method on the basis of conventional western medicine.