Study Of The Therapeutic Value Of Hydrogen Inhalation In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:Chronic obstructive pulmonary disease（COPD）is a serious threat to human health,and the current treatment methods are not ideal.The antioxidant effect of hydrogen inhalation has been confirmed and has obvious therapeutic effect on smoke-induced COPD in rats.Therefore,the improvement of COPD assessment tes,Breathlessness Cough and Sputum Scale,lung function（FVC,FEV₁,FEV₁/FVC%）and blood gas analysis（PH,PCO₂,PO₂）in patients with acute exacerbation of chronic obstructive pulmonary disease by hydrogen inhalation was studied.To evaluate the therapeutic value of hydrogen inhalation in patients with acute exacerbation of COPD.Methods:This is a randomized,double-blind,controlled and prospective clinical trial.42 patients with acute exacerbation of chronic obstructive pulmonary disease in the first Hospital of Hebei Medical University from March 2016 to December 2017 were randomly divided into control group and experimental group with 21 patients in each group.The control group was given routine treatment with 33%oxygen inhalation.The experimental group was given 33%oxygen 66.7%hydrogen inhalation,and the patients in the two groups were inhaled twice a day for 1 hour for 8 days.Breathlessness Cough and Sputum Scale（BCSS）,COPD assessment test（CAT）score,lung function（FVC,FEV₁,FEV₁/FVC%）and blood gas analysis（PH,PCO₂,PO₂）were compared before and after treatment in two groups of patients with acute exacerbation of COPD.Results:After 8 days of treatment,the BCSS,CAT scores of the two groups were improved compared with those before treatment,and the difference was statistically significant（P<0.05）,but there was no statistical difference between the experimental group and the control group（P>0.05）.Lung function（FVC,FEV₁,FEV₁/FVC%）and blood gas analysis（PH,PCO₂,PO₂）showed no significant difference between the two groups before and after treatment（P>0.05）.Conclusion:Inhaling high concentration hydrogen for 2 hours a day did not improve the BCSS,CAT score,pulmonary function（FVC,FEV₁,FEV₁/FVC%）and blood gas analysis in patients with acute exacerbation of COPD.