The Clinical Analysis Of Autoimmune Liver Disease 220 Cases

Objective: Analyze the distribution characteristics,change trend and clinical features of hospitalized patients with autoimmune liver diseases.Method : A retrospective analysis of 220 cases of the trend,clinical features,general condition,clinical manifestation and auxiliary examination with autoimmune liver disease in the second hospital of Dalian Medical University from 1996 to 2016 was conducted.Exclusion of hepatitis virus markers positive,poor drinking history,history of liver toxicity,history of nonalcoholic fatty liver and repeated cases.In 220 cases of autoimmune liver diseases,there were 81 cases of AIH,76 cases of PBC,26 cases of PSC,35 cases of AIH-PBC overlap syndrome,1 case of PBC-PSC overlap syndrome and AIH-PSC overlap syndrome.SPSS 20.0 software,P <0.05 was statistically significant.Results:The trend of autoimmune liver diseases in patients increased year by year,AIH and PBC were the main part among them(36.82%,34.55%).With time developing,AIH,PBC and overlap syndrome are all on the rise.(P = 0.000 <0.05).The fastest was PBC,followed by overlap syndrome,but there was no obvious change in PSC(P=0.455>0.05).Autoimmune liver disease inpatients average age of 60 years,male to female ratio of 1: 5.1,some patients often show symptoms of liver dysfunction(68.82%),there are also some patients with extrahepatic autoimmune disease symptoms(15.45%%),as well as patients with asymptomatic(17.73%).Autoimmune liver disease could be confirmed by biochemical immunology,imaging and liver biopsy.Liver biochemistry of AIH’s ALT,AST were increased mainly,PBC or AIH-PBC’s ALP,GGT were significantly higher than AIH,the TB level of PSC was significantly higher than the other autoimmune liver disease,there were statistical differences by comparison.The ANA detection rate of AIH,PBC and AIH-PBC were obviously higher than PSC(P=0.000<0.05).The karyotype was mainly composed of granule type,granular type and centromere type.From the perspective of imaging,the diagnostic value of MRCP for PSC is better than ERCP and PTCD,also widely accepted by patients.Liver biopsy is the gold standard for diagnosis of autoimmune liver disease.AIH to interface hepatitis-based(91.67%),PBC to cholestasis or bile duct abnormalities mainly(72.73%)and pathology of AIH-PBC besides the pathological features of AIH,there are also different levels of bile duct tissue damage.Autoimmune liver disease patients are usually associated with extrahepatic autoimmune diseases,the most common is Sjogren’s syndrome(39.53%),followed by thyroid disease(22.09%)and is also found in other autoimmune diseases.Confirmed for the first time of autoimmune liver disease complicated by liver cirrhosis’ s proportion was not significantly reduced over time.Autoimmune liver disease was first diagnosed,whether overlap or not has nothing to do with liver cirrhosis(P=0.620>0.05).Conclusion :(1)People with autoimmune liver disease incidence increased over the past decades,AIH are seen more often in the past.In recent years,AIH and PBC accounted for the main part,AIH,PBC,and overlap syndrome all performs upward trend obviously,the fastest rising is PBC.(2)Autoimmune liver disease is common in middle-aged women,clinical manifestations are not specific,biochemical immunology,liver biopsy and other auxiliary examinations are very important,in which the ANA karyotype was mainly composed of granule type,granular type and centromere type.(3)Early diagnosis of autoimmune liver disease is still low(4)Autoimmune liver disease was first diagnosed,whether overlap or not has nothing to do with liver cirrhosis.In the future,we should continue to sum up the disease characteristics,strengthen the diagnosis and treatment of autoimmune liver disease awareness,in order to achieve early detection,early diagnosis and early treatment and there is a great significance to improve the prognosis of patients and improve the quality of life.