Application Research On Diagnose And Differentital Diagnose Of 256 Row CT Perfusion Imaging In Hepatocel Lular Carcinoma?cholangiocarcinoma And Focal Nodular Hyperplasia

PurposeTo analyze hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC)and focal nodular hyperplasia(FNH)of CT perfusion parameters with total liver computed tomography perfusion imaging(CTPI)using 256-slice spiral CT.To evaluate the usefulness of CIPI in diagnosing patients of HCC,ICC and FNH.MethodSixteen patients of HCC(group A),six patients of ICC(group B)and ten patients of FNH(group C)proved by surgery and pathology underwent 256-slice spiral CT perfusion imaging from April to October 2013,which were admitted to the People's Hospital of Hunan Province.Perfusion parameter values of ROIs including most enhanced solid parts,adjacent lesions with 2cm,distant normal liver tissues.The CT perfusion parameter,such as hepatic arterial perfiusion(HAP),portal venous perfusion(PVP),total liver perfusion(TLP),hepatic artery perfusion index(HPI)were got.Results1.The HAP of solid parts of HCC was 40.43�19.97ml/(min.100mg),PVP was 21.34�14.16ml/(min.100mg),TLP was 61.77�30.22ml/(min.100mg),HPI was 66.63�13.55%.The HAP of adjacent lesions was 19.41�9.28ml/(min.100mg),PVP was 46.58�27.09ml/(min.100mg),TLP is 65.98�29.39ml/(min.100mg),HPI is 32.11�11.88%.The HAP of distant liver tissue was 15.57�9.23ml/(min.100mg),PVP is 56.71�24.00ml(min.100mg),TLP is 72.48�26.42ml/(min.100mg),HPI is 22.28�11.37%.The HAP and HPI of solid parts of HCC are higher than that of adjacent lesions and distant liver tissue(P<0.05),which existed statistical difference.The PVP of solid parts was lower than those(P<0.05),also existed statistical difference.The HPI of adjacent lesions was higher than that of distant liver tissue(P<0.05),also existed statistical difference.2.The PVP of solid parts of ICC was 15.23�7.69ml/(min.100mg),TLP was 32.99�9.84ml/(min.100mg),HPI was 55.09�18.05%.The HAP of distant liver tissue is 39.27�14.31ml/(min.100mg),TLP is 57.83�19.34ml/(min.100mg),HPI is 32.68�15.13%.The PVP and TLP of solid parts of ICC are lower than that of distant liver tissue(P<0.05),which existed statistical difference.The HPI of solid parts was higher than that of distant liver tissue in ICC(P<0.05),existed statistical difference.3.The HAP of solid parts of FNH was 66.95�24.53ml/(min.100mg),PVP is 8.49�6.84ml/(min.100mg),HPI is 89.14�4.99%.The HAP of liver in the distance of FNH was 10.37�2.90 ml/(min.100mg),PVP was 44.65�15.06 ml/(min.100mg),HPI was 19.41�2.49%.The HAP and HPI of solid parts in patients of FNH were higher than liver tissues in the distance(P<0.05),the PVP was lower than liver tissue in the distance(P<0.05),which all had statistical differences.4.The HAP and TLP of solid parts of HCC were higher than that of ICC(P<0.05),which existed statistical difference.5.The HAP and HPI of solid parts of HCC were lower than that of FNH(P<0.05),PVP was higher than that of FNH(P<0.05),which all existed statistical difference.6.The HAP,TLP and HPI of solid parts of ICC were lower than that of FNH(P<0.05),which existed statistical difference.7.The time density curve of HCC was "quickly rise and fall",time density curve of ICC was�slow rise and slow drop",the time density curve of FNH was�speed up and slow down".