Chemical Constituents Form Thalitrum Fortunei

ObjectiveIn the early research,we studied on the derivatives of cycloartane triterpene sponins and their pharmacological action,and obtained some good results.And now we decided to make a further study of cycloartane triterpene sponins from Thalitrum fortunei.MethodsCompounds were separated and purified by many kinds of chromatographic methods and the structures were identified by their physicochemical properties and spectroscopic data.ResultsTwenty-one compounds were isolated and identified as 3-O-?-d-glucopyranosyl(1-4)-?-D-xylopyranosyl(22s,24Z)-cycloart-24-en-3?,22,26-triol 26-O-?-D-glucopyranoside(TS C-1)?3-O-?-D-glucopyranosyl(1-4)-?-D-xylopyranosyl(1-4)-?-L-arabinopyranosyl(1-6)-?-D-glucopyranoside(1-4)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,26-triol26-O-(6-O-acetyl-?-D-glucopyranoside)(TSC-2)?3-O-?-D-glucopyranosyl(1-4)-?-L-arabinopyran.osyl(1-6)-?-D-glucopyranoside(1-4)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,26-triol 26-O-(6-O-acetyl-?-D-glucopyranoside)(TSC-3)?3-O-?-D-xylopyranosyl(1-4)-?-L-ara binopyranosyl(1-6)-?-D-glucopyranoside(1-4)-?-D-fucopyranosyl(22S,,24Z)-cycloart-24-en-3?,22,26-triol26-O-?-D-glucopyranoside(TSC-4)?3-O-?-D-glucopyranosyl(1-4)-?-D-fuco pyranosyl(22S,24Z)-cycloart-24-en-?,22,26-tetraol 26-O-(6-O-acetyl-?-D-glucopyranoside)(TSC-5)?3-O-?-D-quinov opyranosyl(1-6)-?-D-glucopyranoside(1-4)-)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,26-tetraol26-O-?-D-glucopyranoside(TSC-6)?thalicfortin e A(TSC-7)?(R)-3-(2,3-hexenol-4-methyl)-1H-pyrrole-2,5-dione(TSC-8)?2-(3-hydroxy-4-methoxyphenyl-ethyl-O-?-D-glucopyranoside(TSC-9)?bergenin(TSC-10)?1-(4-hy droxy-3-ethoxy)-phenyl-2-[4-(1,2,3-trihydroxypropyl)-2-methoxy]-phenoxym-1,3-propandi of(TSC-11)?[4-(2-hydroxyethyl)-2-methoxyphenyl-O-?-D-glucopyranoside](TSC-12)?meliasendanin D(TSC-13)?2-(4-hydroxy-3-methoxyphenyl-ethyl-O-?-D-glucopyranoside(TSC-14)?kizutasaponin K12(TSC-15)?3-O-?-D-glucopyranosyl(1-6)-?-D-glucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,3?-tetraol 26-O-?-D-glucopyranoside(TSC-16)?3-O-?-D-quinovopyranosyl(1-6)-?-D-glucopyranosyl(1-4)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,26-triaol 26-O-?-D-glucopyranoside(TSC-17)?3-O-?-D-glucopyranosyl(1-4)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,30-tetraol 26-O-?-D-glucopyranoside(TS C-18)?3-O-?-D-glucopyranosyl(1-4)-?-D-fucopyranosyl(22S,24Z)-cycloart-24-en-3?,22,30-tetraol 26-0-?-D-glucopyranoside(TSC-19)?1,2,4-benzenetriol(TSC-20)??-stigmaste rol(TSC-21).ConclusionTSC-1?TSC-6 are new cycloartane triterpene sponins;TSC-7?TSC-8 are new alkaloids;TSC-10?TSC-15 are isolated from this plant for the first time.