Effectof Patient-controlledintravenous Analgesiaforhan-uvulopalatopharyngoplastysur GeryonplasmaIL-2 AndIL-6

Objective:Toevaluate the analgesicefficiencyof patient-controlledintravenous analgesia(PCIA)after Han-uvulopalatopharyngoplasty(H-UPPP)and its effect on serum levels of interleukin-2 and interleukin-6.Methods:48 patientsundergoing H-UPPPsurgerywere randomly dividedinto two groups:experimental group(n=24,patient-controlledintravenousanalgesia)and control group(n=24,Nimesulide0.1g,P.O.).TheVAS was observedin the postoperative8h,24h and 48h.The levels of IL-2 and IL-6 inserum were measured in the preoperative and postoperative 8h,24h and 48h.Results:The VAS score of control group was significant higher than thatofexperimental group at both rest and swallow state(P<0.05).The level of IL-6 was increased significantly in the two groups comparing with the level before anesthesia(P<0.05),IL-6 in control group increased significantly compared with that in experimental group at postoperative 8h,24h and 48h(P<0.05).The level ofIL-2in experimental groupwere not significantlydifferent in the preoperative and postoperative.The level of IL-2 in the control groupsignificantly reduced compared with that in experimental group in the postoperative 8h,24h and 48h(P<0.05).Conclusions:The subjective and objective indicators of the experiment show that PCIA can provide safe and satisfactory analgesia for patients with OSAHS after H-UPPP.PCIA is conducive to maintaining the stability of pro/anti-inflamatory cytokines,reducing the immune suppression.