The Correlation Analysis Of Serum Uric Acid And Ca, P And IPTH In Non-dialysis Patients With Chronic Kidney Disease

Objective:To investigate the correlation between serum Uric Acid(SUA)levels and Ca,P,and iPTH in non-dialysis patients with chronic kidney disease(CKD),and to provide a theoretical basis for the prevention and intervention of patients with chronic kidney disease complicated with calcium and phosphorus metabolism disorders.Methods:Select 166 cases of CKD 3-5 non-dialysis patients who were hospitalized in the Department of Nephrology at the First Hospital of Shanxi Medical University from November 2015 to January 2018.The basic conditions of acquiring patients included the underlying primary disease,gender,and age.Uniform instruments and standards for measuring body weight and height,and calculating body mass index(BMI),using a unified instrument to detect biochemical indicators including serum uric acid(SUA),serum creatinine(Scr),urea nitrogen(BUN),serum albumin(ALB)Blood total cholesterol(TC),blood triglycerides(TG),blood calcium(Ca),serum phosphorus(P),alkaline phosphatase(ALP),full-parathyroid hormone(iPTH),fasting blood glucose(FBG).Glomerular filtration rate(eGFR)was also calculated.According to the SUA level of the study subjects,it was divided into two groups: high uric acid group(UA?420?mol/L)and normal uric acid group(UA<420?mol/L).According to the study subject iPTH levels were divided into high i PTH group(iPTH ? 70pg/mL)89 cases and normal iPTH group(iPTH<70pg/m L)77 cases.Chi-square test and t-test were used to compare the differences of clinical indicators between the two groups,and Pearson correlation analysis and Logistic regression analysis were used to further analyze the factors that affect the increase of SUAand iPTH and their correlation with each index.Results:1.Comparison between HUA group and normal uric acid group(1)A total of 166 subjects were studied,68 in the hyperuricemia group(HUA group),39 in males,and 29 in females.Another 98 patients were in the normal uric acid group,including 48 males and 50 females.In the HUA group,there were 22 cases of chronic nephritis,19 cases of diabetic nephropathy,1 case of interstitial nephritis,2 cases of hypertensive renal damage,10 cases of nephrotic syndrome,3 cases of IgA nephropathy,1case of acute kidney injury,and 2 cases of polycystic kidney disease.The other 8 cases.In the normal uric acid group,there were 35 cases of chronic nephritis,27 cases of diabetic nephropathy,2 cases of interstitial nephritis,4 cases of hypertensive renal damage,13 cases of nephrotic syndrome,6 cases of IgA nephropathy,2 cases of acute kidney injury,and 6 cases of polycystic kidney disease.The other three cases.(2)Compared with the normal UA group,the HUA group had significantly higher levels of Scr,BUN,P,iPTH,ALP,and FBG in the HUA group than the normal UA group,and the eGFR was significantly lower than that in the normal UA group(P<0.05).There was no significant difference between primary disease,age,gender,BMI,Ca,TG,TC,and ALB(P>0.05).(3)Using uric acid as an independent variable,Pearson correlation analysis showed that UA was positively correlated with Scr,BUN,P,iPTH,and ALP(P<0.05),and negatively correlated with eGFR(P<0.05).(4)Multivariate logistic regression analysis: BUN,ALP,and eGFR were risk factors for the increase of SUA.2.Comparison between high iPTH group and normal iPTH group(1)Compared with the normal iPTH group,the high iPTH group had significantly higher levels of Scr,BUN,SUA,P,iPTH,ALP,and FBG in the high iPTH group than in the normal uric acid group.The levels of Ca,ALB,and eGFR were significantly lower than those in the normal uric acid group.The difference was statistically significant.(P<0.05);There was no significant difference in age,BMI,TG,TC between the two groups(P>0.05).(2)Using iPTH as an independent variable,Pearson correlation analysis showed that iPTH was positively correlated with Scr,BUN,SUA,P,ALP,and FBG(P<0.05),and negatively correlated with Ca,ALB,and eGFR(P<0.05).(3)Multivariate logistic regression analysis:SUA is not a risk factor for increased iPTH.Conclusion:There was a correlation between SUA and Ca,P,and iPTH in non-dialysis patients with CKD.SUA is a risk factor for calcium and phosphorus metabolism in CKD non-dialysis patients,suggesting that controlling HUA as soon as possible may be beneficial for delaying the development of calcium and phosphorus metabolism disorders in CKD patients.