The Relation Between Hemoglobin Variability And Carotid Atherosclerosis In Peritoneal Dialysis Patients

Objective:To study the relation between hemoglobin variability and carotid atherosclerosis in peritoneal dialysis patients.Methods:68 cases of peritoneal dialysis in the first hospital affiliated of Shan Xi Medica l University Nephrology were enrolled in this study.And underwent the carotid art ery examination by the high-resolution B-mode ultrasonography.Carotid atheroscle rosis can be diagnosed by thickening(CIMT?1 mm)or plaque formation in caro tid artery.The patients were divided into two groups.The carotid atherosclerosis gr oup and the non-carotid atherosclerosis group.General data of patients and clinica l indicators of hemoglobin,albumin,high sensitivity C-reactive protein,?2-microgl obulin were collected.Hemoglobin variability was expressed by residual standard d eviation.The relationship between carotid atherosclerosis with hemoglobin variabili ty and blood biochemical indexes was analyzed.Results:In study,carotid atherosclerosis accounted for 52.9% in 68 patients of periton eal dialysis.Two groups of patients on dialysis compared in hemoglobin variabilit y[(4.73±1.96)mmol/L vs(10.91±5.24)mmol/L],albumin[(41.71±4.07)g/L vs(37.74±3.81)g/L],high sensitivity C-reactive protein[(1.48±0.71)mg/L vs(2.24±1.06)mg/L],tr iglyceride[(1.27±0.55)mmol/L vs(1.60±0.55)mmol/L],total cholesterol[(4.45±0.94)mmol/L vs(5.09±1.08)mmol/L],low density lipoprotein cholesterol[(2.32±0.63)mm ol/L vs(2.79±0.80)mmol/L],?2-microglobulin[(12.85±1.82)mg/L vs(14.13±1.91)m g/L],the difference was statistically significant(P<0.05).Between the two groups,carotid atherosclerosis was positively correlated with hemoglobin variability,high sensitivity C-reactive protein,?2-microglobulin(r=0.683,0.398,0.323,P<0.05),and was negatively correlated with albumin(r=-0.456,P<0.05).The logistic regression analysis showed that,the main influencing factors of carotid atherosclerosis are h emoglobin variability,high sensitivity C-reactive protein,albumin.Conclusion:Hemoglobin variability,inflammation and malnutrition are risk factors for carotid atherosclerosis in peritoneal dialysis patients.Maintaining stable hemoglobin levels and improving inflammation and nutritional status may help reduce atherosclerosis,so as to reduce the incidence of cardiovascular events,and improve the prognosis in patients with peritoneal dialysis.