Research Of Relationship Between Serum FGF-23 And Carotid Artery Intima-media Thickness In Patients With Continuous Ambulatory Peritoneal Dialysis

Objective: The primary purpose is to explore and research the relationship between the levels of serum fibroblast growth factor-23 about patients with continuous ambulatory dialysis(CAPD)in the region and carotid intima-media thicknesses(CIMT).Methods1.The total subjects were 43 patients who took continuous ambulatory dialysis as their therapeutic methods.All of these patients who were chosen to this research followed the exclusion and chosen standards strictly and randomly.And all of them came from peritoneal dialysis therapeutic centers in nephrology departments of Qinghai province people's hospital and the first people's hospital of Xining.2.We collected and recorded the research data of all subjects who were chosen to this study in detail.We collected disease history data such as ages,the times of dialysis treatment,sexes,primary diseases,the durations of diabetes,smoking histories,drinking histories,body mass indexes and other blood biochemical indexes,for exemple,the levels of hemoglobin,total plasma protein,plasma albumin,plasma globulin,blood urea nitrogen,serum creatinine,total cholesterol,triglyceride,high-density lipoprotein,low density lipoprotein,serum calcium,serum phosphorus,serum intact parathyroid hormone,serum FGF-23.3.Each of the subjects had a carotid vascular color ultrasonic inspection.The doctor measured the carotid intima-media thicknesses.We divided these patients into two groups,one of the groups was CIMT?1.0mm,the CIMT increased group,the other was CIMT<1.0mm,we called CIMT normal group.There were 20 patients in the increased group and 23 in the normal group.4.We compared the biochemical indexes of the two groups and we have analysed the differences and the relationships between serum FGF-23 and CIMT.Results1.The proportion of the increased CIMT was 46.51%.The CIMT was1.10±0.20 mm of increased group and significantly higher than the normalgroup(0.64±0.16mm),P<0.001.2.The level of FGF-23 of increased group was 3.126±1.200pg/ml,significantly higher than the normal group 1.450±0.290pg/ml,P<0.001.3.The level of serum phosphorus of increased group was 1.88±0.70mmol/L,significantly higher than the normal group 1.59±0.37mmol/L,P=0.001;the level of serum intact parathyroid hormone of increased group,393.00±355.25pg/ml,was significantly higher than the normal group 111.35±309.38pg/ml,P=0.004.Other biochemical indexes of the groups had no significant differences.4.We had a logistic regression analysis indicated that the level of FGF-23 is the independent risk factor for CIMT(P=0.012,OR=6.037).Conclusions1.The detection rate that CIMT increased of patients who where on peritoneal dialysis(CAPD)is 46.51% in the region.2.The elevated level of serum FGF-23 was the independent risk factor for CIMT.