Analysis On The Relationship Between Serum Transferrin And 25-(OH)D,β-CTX,P1NP In Postmenopausal Women With Type 2 Diabetes Mellitus

Objective:By collecting the age,course of postmenopausal women with type 2 diabetes,height,weight,glycosylated hemoglobin,(density,serum transferrin,25-(OH)D,β-CTX and P1 NP,transferrin postmenopausal women with type 2 diabetes mellitus patients,to explore the coorelation between serum transferrin and 25-(OH)D,β-CTX,P1 NP in postmenopausal women with type 2 diabetes mellitus for early menopause and patients with type 2 diabetes prevention and treatment of osteoporosis to provide simple and scientific clinical reference.Methods:From March 2017 to December 2017 in our hospital in patients with type 2 diabetes endocrinology,aged fluctuations in the 45-75-year-old female patients,according to data integrity,inclusion criteria and exclusion criteria,and chose 123 patients as the research object.The diagnostic criteria for type 2 diabetes are the 1999 diabetes diagnosis standards established by the world health organization(WTO).Exclusion criteria: with the endocrine system disease,kidney failure,blood system tumor,tumor bone metastases and bone tumor,has a history of lumbar spine or hip fracture,various genetic and long-term oral hormone such as volunteers.Basic information of patients:age,duration of disease,height,weight,etc.Laboratory indicators: 25-(OH)D,β-ctx,P1 NP,glycosylated hemoglobin and bone density.The bone density was measured using a double-energy X-ray bone density measuring instrument.Using SPSS23.0 statistical software for statistical analysis: the measurement data is expressed assx ±;the count data is expressed or rate;differences between groups to compare the Kruskal-Wallis test,two indicators using partial correlation analysis.P < 0.05 indicates significant difference.Results:1.In postmenopausal women with type 2 diabetes in age and body mass index in normal bone mass and osteopenia and osteoporosis in the group have differences,with statistical significance(P < 0.05),as the growth of the age of osteoporosis patients increased significantly,at the same time as the body mass index(BMI)to reduce osteoporosis patients also increased obviously,and the course of the disease and no obvious difference was found between glycosylated hemoglobin.2.In postmenopausal women with type 2 diabetes patients with normal bone mass and osteopenia and osteoporosis group among three groups of serum transferrin and 25(OH)D,P1 NP,β-CTX had statistical significance(P < 0.05),transferrin,P1 NP,25-(OH)D with bone mass decreases significantly decreased significantly,while β-CTX with decreased bone mass increases.3.When the body mass index and age were corrected,there was a significant correlation between transferritin and 25-(OH)D,β-CTX and P1 NP in postmenopausal women with type 2 diabetes(P<0.01).The transferrin was positively correlated with P1 NP and25-(OH)D,indicating an increase of 25-(OH)D with the increase of transferrin.Transferritin was negatively correlated with β-CTX,indicating that with the increase of transferrin,β-CTX gradually decreased.Conclusion:1.The prevalence of osteoporosis in postmenopausal women with type 2 diabetes increased with age,and postmenopausal women with type 2 diabetes mellitus with a decrease in body mass index.2.The serum transferrin and 25-(OH)D of postmenopausal women with type 2 diabetes decreased with the decrease of bone density,while the number of β-CTX decreased and increased.3.Postmenopausal women with type 2 diabetes serum transferrin and 25-(OH)D,βCTX and correlated with P1 NP,serum transferrin reduced may affect bone metabolism,leading to the bone to reduce or even the occurrence of osteoporosis.