The Relationship Of Metabolic Syndrome And Bone Mineral Density In Some Urban Areas Of Taiyuan,Shanxi

Objective: Analyze the relationship of bone mineral density in different parts of urban and metabolic syndrome in Taiyuan,Shanxi province.Investigate the effect of different components of metabolic syndrome on bone mineral density in different parts,so as to provide the oretical basis for screening osteoporosis in patients with metabolic syndrome.Methods: Adult residents in some districts of Taiyuan were randomly selected to make a sample survey.489 people aged 20-87 years old were enrolled as the research subjects.All the research objects in the agreement signed informed consent.The research consists of three parts:(1)Questionnaire survey: including gender,age,menopausal status,past history,and oral medicine;(2)Anthropometric measurements: including height,weight,waist circumference,blood pressure,and body mass index;(3)Measurement of biochemical indexes: collected the fasting venous blood,laboratory blood lipid,blood glucose;(4)Bone density measurement: measured lumbar spine,left hip and left femoral neck BMD by dual-energy X-ray absorptiometry.The metabolic syndrome is defined according to the Asians standard of the American Heart Association/National Heart,Lung and Blood Institute(AHA/NHLBI).The data were statistically processed with SPSS 22.0 statistical software.P < 0.05 indicates significant difference.Results: 1.Divided subjects into three groups according to gender and menopause: men,premenopausal,and postmenopausal women.There are differences in all baseline characteristics such as anthropometric measurements,biochemical indexes,and BMD among men,premenopausal,and postmenopausal women.The difference was statistically significant(P < 0.001).2.In males,premenopausal,and postmenopausal women,there was no significant difference in BMD at any site between the MS group and the non-MS group.3.Analyzed the changes in BMD according to the number of MS components at the LS,LH and LFN.No association was observed between the the number of MS components and BMD at any site.4.Analyzed the association of BMD at different sites linear regression with cardiometabolic risk factors.In male,BMD shows positive correlations with BMI;LS BMD is negatively correlated with total cholesterol;LH and LFN BMD are negatively correlated with age.In postmenopausal women,LS,LH,and LFN BMD are negatively correlated with age;LS BMD shows positive correlations with waist circumference.5.Analyzed the ORs(95 % CI)of increment in LS,TH,and FN BMD for each cardiometabolic risk factor.LS BMD in male,premenopausal and postmenopausal women increased associated with obesity.The increase in male LS BMD is associated with hypertriglyceridemia.In premenopausal and postmenopausal women,LFN BMD are associated with hypertriglyceridemia.Conclusion: 1.There is no correlation between MS and BMD in LS,LH and LFN in some urban areas of Taiyuan,Shanxi province.2.The increase of BMD may be associated with hypertriglyceridemia.3.BMD reduction in the lumbar spine is associated with high cholesterol.4.Age is a risk factor for osteoporosis.5.Obesity is a protective factor for osteoporosis.