Correlation Between Eosinophils And Coronary Heart Disease

Objective:As China enters the stage of building a well-to-do society in an all-round way,and the people's economic level and living standards have improved,the number of people with high symptoms of “hypertension,hyperlipidemia,and hyperglycemia” has gradually increased,resulting in coronary heart disease.The incidence of disease,hospitalization rate,and mortality rate all show an increasing trend,which not only brings unprecedented mental burden to patients and their families,but also brings a huge economic burden to the country.Therefore,the pathogenesis of atherosclerosis has become the focus of cardiovascular disease.The current research field involves blood uric acid,C-reactive protein,red blood cell volume width,white blood cell count,platelet count,neutrophil count,neutrophil The cell/monocyte ratio can be used as an indicator of coronary atherosclerosis.Blood cell analysis is one of the items that must be checked after admission,and it has the advantages of being simple,timely,and fast.In recent years,eosinophils involved in the formation of blood clots have attracted much attention.The purpose of this study was to investigate eosinophilic particles.The relationship between the number of EOS counts and coronary lesions,number of branches,and location of coronary heart disease.Methods:We selected 248 inpatients who underwent coronary angiography(CAG)in our hospital as the study subjects.All patients were taken 5 ml of fasting venous blood after admission.The blood routine was tested with BECKMAN DXH800 hematology analyzer.The reference range of EOS was(0-3)×10./L.Blood biochemistry Total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)were measured by the BECKMANAU 5800 biochemical analyzer,and coronary artery changes were determined based on CAG results.Severity,number of lesions and sites,monitoring EOS counts and blood lipids in patients' blood routine,and comparing the differences between different disease groups.Results:The number of hypertensive patients(P=0.000),age(P=0.027),TC(P=0.000),and LDL-C(P=0.001)levels in coronary heart disease group were significantly higher than those in the control group(P< 0.05).The number of hypertensive patients(77% vs 49%)and age(60.990±10.223 vs 58.030±10.389)were higher in coronary heart disease group than in control group,while TC in coronary heart disease group(4.005±1.069 vs4.532±1.023),LDL-C(2.200±0.866 vs 2.571±0.925)were lower than those in the control group.The difference of EOS,TC and LDL-C between control group,acute myocardial infarction group and unstable angina group was statistically significant(P<0.05).The difference in EOS between the acute myocardial infarction group and the control group and the unstable angina group was statistically significant(P = 0.015,0.001 respectively).The EOS in the acute myocardial infarction group was significantly lower than that in the control group and the unstable angina group(0.040±0.455 vs 0.130±0.105,0.040±0.455 vs 0.165±0.271).The EOS of three-vessel disease group was significantly higher than that of single-vessel disease group(P=0.008).The EOS of three-vessel disease group was significantly higher than that of single-vessel disease group(0.174±0.351 vs0.093±0.097).There were significant differences in EOS,TC,and LDL-C between the 5groups of coronary artery lesions(P<0.05).There was a statistically significant difference between the EOS of LAD group and the control group and multi-site disease group(P values were 0.022,respectively 0.005).Conclusion:EOS is associated with the type of coronary heart disease,the number of coronary lesions,and the location of lesions.It has a certain evaluation value.