Analysis Of Compliance With Dermatophagoides Farinae Drops In Patients With Bronchial Asthma Allergic To Dust Mites

Objective:To analysis of compliance with the Dermatophagoides Farinae Drops treatment of dust mites allergy in patients with mild to moderate bronchial asthma,and summarizes the corresponding countermeasures.Date and Methods:Clinical data:Two hundred and twelve patients with mild to moderate bronchial asthma sensitized to dust mites were diagnosed in the outpatient department of Respiratory Department,first Hospital of Shanxi Medical University from March 15,2016 to September 15,2016.Among them,they are 18-64,the average age was 38.1±4.5 years(74 males and 137 females).All the patients were above positive for Dermatophagoides farinae and/or house dust mite skin prick test.Among them,one hundred and six patients with better economy were tested for serum IgE at the same time,including 38 males and 68 females.In a ddition to mites,these patients were allergic to cat hair,dog hair,cockroaches,egg whites,milk,molds,wormwood and tree pollen.More than three substan ces were detected in 76 patients,including 32 males and 44 females.Treatment methods:All patients with asthma began to Sublingual Immunotherapy(SLIT)with FEV1>70%expected value,and the classification of the control of asthma condition was in complete control and partial control.SLIT begins with the standardized treatment of asthma.All patients received standard Dermatophagoides Farinae Drops drug(SLIT)for Zhejiang Wolwo Bio-Phar maceutical Co.,Ltd.(Wolwo Pharma)production.Patient education in detail with doctors and professional nurses before SLIT treatment.Then,the patients were randomly divided into two groups:the control group(n=87),including 30males and 57 females,with an average age of 37.1±3.3 years.Inform patients of regular outpatient follow-up and attend specialist patient education courses in asthma and the observation group(n=125),44 males and 81 females,with an average age of 38.7±4.8 years.Whole course patient education,nurses actively follow up,set a schedule of follow-up dates,remind them by phone before the follow-up day arrives,open mobile follow-up tools(SMS or WeChat)for asthma patients,solve the problems encountered during desensitization,etc.SLIT treatment process had regular telephone return visit once a month.Asthma upgrade and degrade therapy was evaluated every three months.Inform the patient th at if there is an acute attack,the patient should be treated at any time.Sublingual Dermatophagoides Farinae Drops treatment in patients with bronchial asthma are follow-up time for one year.To observe the shedding condition of two groups of patients treated with SLIT for one year and the reasons for stopping treatment.Results:1.In one year,drop out of the number was 92,and total shedding rate was 43.40%.Among them,the control group was in the fall of 47 cases,sheddi ng rate of 50.02%.The observation group,45 cases dropped out and the shedding rate reached 36.00%.There was a statistical difference between the two gr oups in the rate of exfoliation(c~2=6.783,P=0.009).2.The control group was 47 men fell off,and the shedding rate of 66.67%(20/30),and the female dropped out of 27,accounting for 47.37%(27/57)of the female shedding rate.In the observation group,27 men dropped out,and the rate of shedding was 61.36%(27/44),and 18 women dropped out,and the shedding rate was 22.22%(18/81).3.Separate records Shedding of Monthly telephone follow-up or outpatient follow-up.The number of shedding patients in the fourth month was 16.The proportion of the total number of follow-up in that month was 10.25%(16/156),is the highest time for the number of drop people to fall off during the whole year.Secondly,the number of shedding in the ninth month of follow-up was 13.The proportion of the total number of follow-up in that month was 8.50%(13/153),which was the second highest time in the year of follow-up.4.The number of people who stopped taking the medicine after the symptoms were well controlled was the most,who was 45.65%.The proportion of other causes for withdrawal is as follows:inconveniences(19.57%)?drug cost(15.22%)?telephone changes that cannot be linked(5.43%)?drug adverse reaction(4.35%)?recurrent symptoms lead to a loss of confidence(4.35%)?pregnancy(1.08%)and so on(travel,relocation,unknown cause)(4.35%).5.With the extension of follow-up time,the total number of shedding patient increased.Most of shedding patient were for those who stopped taking medicine after their symptoms were well controlled.Analyze this part of the patient,the time of shedding was distributed during the 4-6 months follow-up.Conclusion:The shedding rate of the SLIT patients was up to 43.40%in one year.The men have a higher shedding rate.The shedding rate of the observation group was significantly lower than that in the control group.The shedding rate inc reased after three months of treatment,which was mainly due to the withdrawal of the drug after the patients'symptoms were well controlled.It was mainly concentrated in the 4-6 months of follow-up.It is possible to improve compliance with the treatment at different times and different sexes to targeted supervisi on and urgency.It can also obviously improve therapeutic compliance by paying attention to regular patient education,introducing patient-centered care,activing follow-up and sharing strategies.