Changes And Significance Of Serum AFABP With Preoperative And Postoperative Of PCI In Patients With Coronary Heart Disease

Objective:To determine the changes of adipocyte fatty acid binding protein(AFABP)and interleukin-6(IL-6)with preoperative and postoperative of PCI in patients with coronary heart disease.Methods:Collect 66 cases of coronary artery involvement in The First Affiliated Hospital of Shanxi Medical University,according to the clinical features,there were 23 cases of acute myocardial infarction(AMI)group,21 cases of unstable angina(UAP)group and 22 cases of stability angina(SAP)group.According to Gensini,the subjects were divided into mild,moderate,and severe coronary artery subgroups.A total of 20 patients with coronary angiography were selected as the control group.The subjects were taken from the hospital the next day(or before the operation)and the next day after the operation,and the AFABP and IL-6 were detected.Results:Compared with the control group,the serum AFABP and il-6 levels increased in all groups.The serum AFABP and il-6 of the AMI group were significantly higher than those of the other two groups.The differences between mild,moderate and severe coronary stenosis were statistically significant.Except the normal control group,the serum AFABP and il-6 levels of the postoperative patients in each group decreased,and the differencewas statistically significant.There was significant correlation between serum AFABP and IL-6 before and after surgery.Conclusion:The AFABP association with IL-6 may better reflect the inflammatory state of the coronary artery,which can be used to assess the degree of coronary stenosis and long-term follow-up of patients with coronary heart disease,especially postoperative patients with PCI.