To Observe The Clinical Effect Of Jiawei Sangbaipi Decoction In Treating Acute Exacerbation Of The Senile Chronic Obstructive Pulmonary Disease With Tanreshenxu Syndrome

Objective: To Observe the clinical efficacy and safety of Jiawei Sangbaipi Decoction in treating acute exacerbation of the elderly patients with chronic obstructive pulmonary disease which belong to tanreshenxu syndrome,and provide theoretical basis for its clinical application.Method:The 64 patients diagnosed tanreshenxu syndrome of acute exacerbation in the elderly patients with chronic obstructive pulmonary disease were all from the respiratory deparment of Teaching Hospital of chengdu university of TCM,which were divided into treatment group and control group by random-controlled number table method,32 cases of each group.Patients in control group were treated with western medicine,and patients in the treatment group were treated with oral administration of Jiaweisanbaipi decoction on the basis of western medicine.The period of treatment is 2 weeks.To compare TCM syndrome integral,the leukocyte count,the percent of neutrophile granulocyte,C-reactive protein,procalcitonin,arterial blood gas analysis and COPD Assessment Test before and after treatment with each group in order to evaluate the curative effect of Jiawei Sangbaipi Decoction.Meanwhile,routine of blood,urine,stool,liver and renal functions,electrolytes and electrocardiogram examination,were the evaluation indicators for clinical safety of the experiment.Results:1.Clinical curative effect comparison: Two weeks after the treatment,the control group and the treatment group can significantly improved patients with the curative effect of traditional Chinese medicine(P<0.01).Comparing with the control group,the clinical curative effect had significantly increased in the treatment group(P< 0.05).2.The integral comparison of clinical symptom:Two weeks after the treatment,the control group and the treatment group can significantly improved patients with the score of traditional Chinese medicine(P<0.01).Comparing with the control group,the score of treatment group had significantlydecreased(P<0.05).3.The comparision of bacterial infection markers : Two weeks after the treatment,the bacterial infection markers(the leukocyte count,the percent of neutrophile granulocyte,C-reactive protein,procalcitonin,)of the control group and treatment group were significantly decreased(P<0.01).Comparing with control group,the treatment group was sig-nificantly decreased(P<0.05).4.The comparision of arterial blood gas analysis:Two weeks after the treatment,the partial pressure of carbon dioxide in artery levels of the control group and treatment group were significantly decreased and the partial pressure of oxygen in artery levels of the control group and treatment group were significantly increased(P<0.01).Comparing with the control group,the partial pressure of carbon dioxide in artery was significantly reduced and the partial pressure of oxygen in artery was significantly increased of the treatment group(P< 0.05).5.The comparision of CAT scores: Two weeks after the treatment,the CAT scores of both the control group and treatment group have significantly improved(P<0.01).Comparing with the control group,the CAT scores were significantly reduced of the treatment group(P< 0.05).6.Security: During the clinical trial,there were no obvious abnormalities in routine of blood,urine and stool,liver and renal functions,electrolytes and electrocardiogram.Conclusion:Jiawei Sangbaipi Decoction can obviously improve the TCM syndrome integral of acute exacerbation of the elderly patients with chronic obstructive pulmonary disease which belong to tanreshenxu syndrome,and improve the patients' life quality on the basis of general western medicine.In this study,we consider Jiawei Sangbaipi Decoction is the effective prescription for the elderly patients with acute exacerbation of chronic obstructive pulmonary disease which belong to tanreshenxu syndrome.No adverse reaction was found after treatment.So that it is safe to use in clinic.