Study On The Relationship Between Helicobacter Pylori Infection And Colorectal Tumor

ObjectiveHelicobacter pylori(H.pylori,Hp)was established in 1994 by the WHO International Agency for Research on Cancer(IARC)as a class?carcinogen for gastric cancer.In recent years,with the recognition of the carcinogenic effect of helicobacter pylori,many studies have found a correlation between helicobacter pylori infection and other gastrointestinal tumors.The relationship between colorectal cancer,colorectal adenoma and helicobacter pylori is a hot topic among many scholars,however,there is no consistent conclusion about the correlation between colorectal tumor and helicobacter pylori infection.Most scholars believe that helicobacter pylori infection increases the risk of colorectal adenoma and colon cancer,and some studies show that there is no correlation between the two.This study analyzed the infection of helicobacter pylori in different pathological types of colorectal tumors to explore the relationship between helicobacter pylori infection and the occurrence and development of colorectal tumors.MethodsA total of 144 patients with colon polyps from October 2015 to October 2017 were collected and classified as non-adenomatous polyps(66 patients)and adenomatous polyps(78 patients)according to pathological types.At the same time,there were no abnormalities in colonoscopy(70 patients)as a control group.The age difference of the group was compared by one-way anova,the gender difference of the group was compared with chi-square test.The infection rate of helicobacter pylori was analyzed retrospectively,in the control group,nonadenomatous polyp group and adenomatous polyp group,the differences in the infection rate of helicobacter pylori were investigated by chi-square test.The adenomatous polyp group was divided into proximal colon and distal colon according to the growth site of adenoma,the maximum diameter is divided into<1cm and?1cm,the number is divided into single and multiple,according to the pathological classification,there were low,high grade epithelial neoplasia and no low,high grade intraepithelial neoplasia,the differences of helicobacter pylori infection in each subgroup were compared by chi-square test.ResultsThere was no significant difference in the distribution of general data(age,gender)between the control group,non-adenomatous polyp group,and adenomatous polyp group(P>0.05).The positive rate of helicobacter pylori was 71.2%(47/66)in the non-adenomatous polyp group,70.5%(55/78)in the adenomatous polyp group,and 50%(35/70)in the control group.The positive rate of helicobacter pylori in the first two groups was higher than those in the control group,the differences were statistically significant(x~2=6.385?6.514,P<0.0167).The positive rate of helicobacter pylori in non-adenomatous polyps was slightly higher than that of adenomatous polyps,the difference was not statistically significant(x~2=0.008,P=0.927).The adenomatous polyps group was divided into subgroups according to the growth site,maximum diameter,number,and pathological type.The positive rate of the proximal colon and distal colon was 78.1%and 65.2%,and the difference was not statistically significant(x~2=1.512,P=0.219);The positive rates of the<1cm group and the?1cm group were71.4%and 69.0 respectively,and the difference was not statistically significant(x~2=0.053,P=0.818);The positive rate of single and multiple was 66.7%and 75.0%,the difference was not statistically significant(x~2=0.647,P=0.421);The presence of low-grade,high-grade intraepithelial neoplasia and no-low,high-grade intraepithelial neoplasia was 58.3%and 72.7%,the difference was not statistically significant(x~2=1.012,P=0.314)(P>0.05)?Conclusion1.Helicobacter pylori infection may increase the risk of colorectal cancer.Helicobacter pylori may be one of the risk factors for the occurrence and development of colorectal cancer.2.There was no significant correlation between the growth site,size,number,and pathological types of H.pylori infection and colorectal tumors.