The Effects Of Dexmedetomidine And Propofol On Emergence Agitation In Children After Sevoflurane Anesthesia

Objective Sevoflurane(sevoflurane)is a common anesthetic in pediatric surgery under general anesthesia.It has the characteristics of rapid onset,smooth anesthesia and rapid reviva。But sevoflurane has a considerable incidence of agitation in practical application,which increases the difficulty of clinical management and affects the postoperative recovery of children.Many studies have shown that,compared with sevoflurane alone,sevoflurane combined with sevoflurane(sevoflurane)in pediatric general anesthesia can reduce its agitation accordingly.Under BIS monitoring,right metomomidin and propofol were used to use two kinds of drugs in children after sevoflurane general anesthesia.Students were compared to obtain more satisfactory anesthetic effect and reduce postoperative complications.Methods A total of 60 cases of elective surgery in the Affiliated Hospital of Qingdao University,age 2-7 years old,ASA grade I-II,all patients were free of systemic disease,the operation time was less than an hour,they were randomly divided into dexmedetomidine group(group D)and propofol group(group P),according to the prepare standard preoperative,2 groups of children were selected sevoflurane induced anesthesia started,given fentanyl 2ug/kg,Phenylsulfonic cisatracurium 0.1mg/kg intravenous injection,D group were first given intravenous dexmedetomidine 1ug/kg load,then by continuous infusion 1ug·kg-1·h-1 in operation,P group with intravenous propofol continuous pump into the 2mg·kg-1·h-1 during surgery,intraoperative BIS monitoring,which will remain at 40-60,to ensure the proper depth of sedation.At the same time,concentration,operation time,anesthesia time,the end of operation time to recovery of spontaneous breathing after PACU,when consciousness,breathing,muscle strength index reached extubation tracheal extubation,postoperative extubation time,recovery time,and according to the pediatric anesthesia emergence delirium(PAED)scale given the agitation score.Results The two groups of children completed the operation successfully.No intraoperative or postoperative adverse events such as bleeding and reoperation occurred within 48 hours.There was no significant difference between the two groups in age,weight,gender,operation time,and anesthesia time(P>0.05).The inspiratory rate of children in the dexmedetomidine group(D group)was lower than that in the propofol group(P group)(P<0.05).There was no statistical difference in nausea and vomiting events.Conclusions Compared with propofol combined with sevoflurane,dexmedetomidine combined with sevoflurane can reduce the agitation of children in recovery stage to a certain extent.