A Meta-analysis On The Relationship Between Helicobacter Pylori Infection And Psoriasis And Oral Lichen Planus

Objective:In this study,Meta analysis was used to explore the relationship between Helicobacter pylori infection and psoriasis and oral lichen planus in order to provide a reference for the clinical treatment of psoriasis and oral lichen planus,and to further explore the pathogenesis of psoriasis and oral lichen planus induced by Helicobacter pylori infection.Method:We searched the CNKI、VIP、Wanfang database and Pubmed database.According to the set and exclusion criteria,the relevant literature was included.The inclusion criteria include:(1)Case control study,cohort study and cross-sectional study on the relationship between Helicobacter pylori infection and psoriasis or the relationship between Helicobacter pylori infection and oral lichen planus published at home and abroad.(2)Case group is psoriasis or oral lichen planus diagnosed by clinical manifestation or pathology.(3)Control group is healthy without psoriasis,oral lichen planus and other diseases.Exclusion criteria include:(1)incomplete data and inaccessible literature.(2)Summary,lecture,and review literature.(3)For the literature published by different authors for the same population or the multiple submissions,we choose the latest or most complete literature and remove redundant literature.And the Stata14.0 software was used to carry out Meta analysis of the obtained data.The heterogeneity detection was used to selected studies.The odds ratio(OR)and the 95%confidence interval(95%CI)were calculated,and the p values were interpreted by Z test.Regression analysis was carried out on different sources and Helicobacter pylori detection methods in different literature,and subgroup analysis was carried out for the factors of heterogenous origin.The reliability of the results was detected by sensitivity analysis,and the publication bias was detected by Harbord’s test.Result:(1)A Meta-analysis on the relationship between helicobacter pylori infection and psoriasis11 studies were enrolled and heterogeneity exits between these studies(I~2=82.3%,p=0.000).The rate of Helicobacter pylori infection in psoriasis patients(59.42%)was significantly higher than that in the control group(40.86%)with a pooled OR of 2.91(95%CI:1.68-5.05).And the difference has significant statistical significance(p=0.000<0.05).Regression analysis showed that different detection methods and different distribution areas were not the factors of heterogeneous sources.Sensitivity analysis showed that the results are reliable.The publication bias analysis showed no significant bias.(2)A Meta-analysis on the relationship between helicobacter pylori infection and oral lichen planus9 studies were enrolled and heterogeneity exits between these studies(I~2=87.5%,p=0.000).The rate of Helicobacter pylori infection in psoriasis patients(47.51%)was significantly higher than that in the control group(29.54%)with a pooled OR of 6.57(95%CI:1.77-24.36).And the difference has significant statistical significance(p=0.005<0.05).Regression analysis showed that different detection methods were not the factors of heterogeneous sources and different distribution areas were the factors of heterogeneous sources.Subgroup analysis showed that different distribution areas could influence the results.Sensitivity analysis showed that the results are reliable.The publication bias analysis showed no significant bias.Conclusion:(1)Helicobacter pylori infection was associated with an increased risk of developing the psoriasis.Different detection methods and different distribution areas are not the factors of heterogeneous sources.(2)Helicobacter pylori infection was associated with an increased risk of developing the oral lichen planus.Different distribution areas were the factors of heterogeneous sources.Domestic data showed that helicobacter pylori infection was associated with the incidence of oral lichen planus and the foreign data did not support this view.Different detection methods were not the factors of heterogeneous sources.