The Expression Of CC16 In The Blood And BALF Of Patients With Pneumoconiosis Of Coal Workers

Purpose: to test in the blood and BALF of the coal workers pneumoconiosis patient CC16 expression level,for the disease prevention,early diagnosis and treatment of drug opened up broad prospects.Methods: to collect the zibo occupational disease prevention and control of hospital in 2012-2016 coal workers pneumoconiosis patients blood and BALF,determination of CC16 values,and lung function measurement index of the object of study,blood gas analysis values,six minutes walking experiments,determination of evaluation data such as anxiety,and statistical analysis.Results:(1)there was no statistically significant difference in lung function between different types of coal miners.VC,FVC,FEV1 periods pneumoconiosis patients was 1.76 + /-0.65,1.64 + /-0.74 and 0.74 + /-0.55,3.36 + /-0.75 were significantly lower than the control group,3.26 + /-0.74 and 0.74 + /-0.64(P < 0.01),and patients with stage I pneumoconiosis FEV1 / FVC(%)was 65.58 + /-20.98 lower than the coal miners of 80.45 + /-12.13(P < 0.05),while patients with stage II FEV1 / FVC(%)was 74.56 + /-20.14,FEV1/FVC(%)of patients with stage III pneumoconiosis was 74.90 + + 2.26.Compared with the coal mine workers group,there was no statistically significant difference between the groups(P BBB 0 0.05).The value of DLCO(%)in pneumoconiosis patients was 76.67 + + 13.24,67.34,plus or minus 15.46 and 45.45,plus or minus 13.24,with significant differences between 87.67 and + 14.56 in the control group(P<0.05).Further to the indicators of lung function as the dependent variable,independent variable is set to age,seniority,weight,smoking,alcohol consumption,type of work and pneumoconiosis in installment,with multiple linear regression to screening of the influence factors of lung function,regression analysis found that: Stage I pneumoconiosis patients with VC and FEV1,FEV1 / FVC and DLCO(%)(%)compared with coal miners,are lower than mine workers,patients with stage II pneumoconiosis VC and FEV1 and DLCO(%)compared with those of mine workers were lower than mine workers,phase III FEV1 pneumoconiosis patients compared with coal miners,below mine workers(P < 0.05),and the VC,FCV and DLCO ratio(%)were decreased with increasing age,FEV1 decreased with increasing of length of service.(2)there was significant difference between SOD activity in BALF(P<0.05),and the total protein content in BALF increased in the same period.The number of cells,macrophages,lymphocytes and neutrophils in the cells of the coal workers' pneumoconiosis were statistically significant compared with the control group(P<0.05).There were statistically significant differences between the number of lymphocytes and neutrophils between different stages of pneumoconiosis(P<0.05).(3)the expression of CC16 in the serum of coal workers' pneumoconiosis patients was 10.21 plus or minus 4.12,8.23 plus or minus 2.05 and 6.22 + 1.48,all lower than the control group of 16.54 + 4.12,and the difference was statistically significant(P<0.05).Test BALF of alveolar lavage(collect)postoperative CC16 value,get CC16 value of coal workers pneumoconiosis patients and the control group,the coal workers pneumoconiosis patients serum CC16 expression was 23.21 + /-7.56,24.53 + /-6.75 and 6.75 + /-4.48,lower than 32.54 + /-10.12 in the control group,difference has statistical significance(P < 0.05).(4)compared with the control group,PCO2,PO2 and SaO2 were statistically significant(t=4.352,4.243,3.254;P=0.035,0.046,0.021).There were statistically significant differences between patients with pneumoconiosis(P<0.05).There was a significant difference between the pneumoconiosis group and the control group(P<0.05).There was also significant difference between the DCW(m)results of other pneumoconiosis groups(P<0.05).The anxiety scores of the pneumoconiosis group were higher than that of the control group,and the difference was statistically significant(P<0.05).Compared with the anxiety scores between different pneumoconiosis stages,the higher the pneumoconiosis,the higher the anxiety score,and there was a significant difference between the groups(P<0.05).(5)FEV1/FVC(%)and CRP(mg/L)were correlated with serum CC16,and the indexes of correlation with the CC16 indicators in BALF were VC(L),FEV1/FVC(%)and CRP(mg/L).The level of CC16 expression in serum of patients with different lung function injuries in pneumoconiosis group was statistically significant(P<0.05).Conclusion: CC16 participated in the pneumoconiosis occurrence and development of pathological process,after further study,the index may be pneumoconiosis related biomarkers of hematology.