Safety And Efficacy Of Indobufen In The Prevention Of Deep Vein Thrombosis In Patients Undergoing Surgery For Superficial Varicose Veins In The Lower Extremities

Objective: This study was designed to prevent deep vein thrombosis(DVT)by indomethacin administered orally and low-molecular-weight heparin(LMWH)injected subcutaneously in patients undergoing surgery for superficial varicose veins of the lower extremities.The safety and efficacy of the two drugs in prevention of DVT were compared,thereby providing more clinical basis and reference for the use of indobufen in the prevention of postoperative thrombosis in clinical practice.Methods: A total of 80 patients receiving surgery for superficial varicose veins of the lower extremities in our hospital from December 2017 to March2018 were randomly divided into indobufen tablet group(experimental group;n=40)and LMWH group(control group;n=40).All patients enrolled underwent routine laboratory tests(routine blood tests,routine coagulation tests,biochemical tests,routine urine test,and D-dimer testing).Deep venous patency of the lower extremities was confirmed on ultrasonography.Subsequently,high-ligation and segmental stripping of great saphenous vein of the lower extremity were performed.Patients in the experimental group(n=40)were treated by oral indobufen tablets(one tablet twice daily for 7 days)for anticoagulation12 hours after surgery,where as those in the control group received subcutaneous injection of LMWH(6400iu twice daily for 7 days)for anticoagulation 12 hours after surgery.All patients in both groups were required to wear elastic bandages and get out of bed the next day after surgery.On the 15 th day after surgery,a series of tests,including lower extremity venous ultrasonography,routine blood tests,routine coagulation tests,biochemical tests,routine urine test,and D-dimer testing,were performed on patients in the two group.The differences in preoperative and postoperativetest results were compared between the two groups,thus observing the safety and efficacy of indobufen tablets in preventing postoperative DVT.Results:1.At 15 days after high-ligation and segmental stripping of great saphenous vein of the lower extremity in both groups,ultrasonography revealed no DVT of the lower extremities in the experimental group and the control group.There was no significant difference between the two groups(P>0.05).D-dimer did not differ significantly before surgery and 15 days after surgery(P>0.05).2.Subcutaneous congestion was observed in 2 and 9 patients in the experimental group and the control group respectively,suggesting significant differences(P<0.05).Gastrointestinal discomfort was reported in 4 patients in the experimental group and 1 in the control group.There was no statistical difference between the two groups(P>0.05).No significant differences were observed in conventional coagulation indexes between the two groups(P>0.05).Conclusions:1.Indobufen can effectively prevent postoperative DVT.2.Oral indobufen does not increase the risk of bleeding in postoperative antithrombotic formation and leads to minimal gastrointestinal reactions.