The Trend Of Hyperuricemia And Its Correlation With Phlegm-wet Type: A Case Control Study

Objective:To investigate the trend of hyperuricemia and the risk factors associated with phlegm-wet type by using the method of nested case-control study.Methods:A total of 539 health examiners from a unit in the Health Management Center of Bethune International Peace Hospital of the Chinese people's Liberation Army(PLA)were selected as the cohort in this study,and blood uric acid(UAA)was used as the exposure factor,and a follow-up survey was conducted for six consecutive years from 2011 to 2016.To study the change trend of HUA.Using the nested case-control study,135 cases of HUA(male 128,female 7)in the cohort were selected as the case group.According to the 1:2 matching method,270 cases(256 males and 14 females)were selected as the control group.Univariate and multivariate conditional logistic regression analysis was used to investigate the risk factors associated with HUA and phlegm dampness type.Results:1.The changing trend of HUAThe prevalence of HUA was8.16%?8.72%?10.02%?10.58%?11.13%?11.32% from 2011 to 2016,respectively,showing an upward trend year by year.The prevalence rate of males was 8.64%?8.86%?10.54%?11.60%?12.03%?12.24%,showing an upward trend year by year.The prevalence rate of female is not regular.2.Baseline data characteristics of two groups of subjects(1:2 match)In the case group,SUA,body weight,the body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),waist circumference(WC),hip circumference,waist-to-hip ratio(WHR),total cholesterol(TC),triglyceride(TG)were significantly higher than those in the control group(P<0.01,P<0.05).There was no significant difference in FGP between the two groups(P > 0.05).3.Univariate conditional Logistic regression analysis(1:2 match)By using backward stepwise(Backward:LR)analysis,the variables selected were sex,body weight,SBP,WC,TC and TG,among which the significant variables were WC,TC and body weight(P<0.01,P<0.05).4.Multi-factor conditional logistic regression analysis(1:2 match)By using forward stepwise(Forward:LR)analysis,the variables selected were body weight,SBP,WC,TC and TG.among which the significant variables were WC,TC and TG(P<0.01,P<0.05).Conclusion:1.The prevalence rate of HUA in general staff of Shijiazhuang is increasing year by year,in which the prevalence rate of male is increasing year by year,but the regularity of prevalence of female is not obvious.2.The main suspected risk factors associated with the occurrence of HUA were WC,TC,TG,SBP and body weight.The occurrence of HUA may be related to autotype(phlegm-dampness type)and some metabolic factors.3.The phlegm-dampness type was significantly correlated with the incidence of HUA in general staff in Shijiazhuang.