Clinical Observation Of Huashi Jiangzhuo Decoction In The Treatment Of Hypertension Complicated With Hyperuricemia (Phlegm Dampness And Blood Stasis Obstruction Syndrome)

Objective:The purpose of this study was to evaluate the efficacy of self-designed transforming dampness and descending turbidity soup for hypertension combined with hyperuricemia(phlegm-dampness and blood stasis obstruction syndrome)in lowering blood pressure,uric acid and improving symptoms by observing its effects on patients’ blood pressure values,serum uric acid levels and TCM syndrome scores.Methods:From December 2019 to January 2021,45 patients with hypertension combined with HUA(phlegm-dampness and blood stasis obstruction syndrome)who met the inclusion and exclusion criteria were collected from the outpatient and inpatient departments of the Department of Traditional Chinese Medicine of the First Hospital of Shanxi Medical University and randomly divided into 3 groups with 15 patients in each group: the group of simple antihypertensive drugs(group A),given amlodipine besylate tablets 5 mg orally once daily.The group of antihypertensive drugs combined with Chinese herbal medicine(group B),on the basis of group A,given self-designed transforming dampness and descending turbidity soup(basic prescription mainly composed with: Cinnamomi Ramulus 6g,Atractylodes Lancea 30 g,Glabrous greenbrier rhizome 30 g,Dioscoreae Septemlo Bae Rhizoma 30 g,Plantaginis Semen 30g),which uniformly used granules from our Chinese herbal dispensary was taken with boiled water twice daily in the morning and evening.The group of antihypertensive drugs combined with uric-acid-lowering drugs(group C),on the basis of group A,given febuxostat 40 mg orally once daily.Four weeks was a course of treatment,with weekly follow-up visits,and the observation time was one course of treatment.The patients’ basic information,medical history,blood pressure,serum uric acid value,TCM syndrome score,three major routine,liver and kidney function,and adverse reactions were collected and recorded before and after treatment.Statistical analysis was used to evaluate the efficacy and safety.Results:Before treatment,the differences in basic conditions(including sex,age,BMI index,course of disease,smoking and drinking),blood pressure,serum uric acid level and TCM syndrome scores were not statistically significant among the groups(P > 0.05),and the data of each group were comparable.Changes in blood pressure levels and antihypertensive efficacy: the blood pressure level of each group after treatment was lower than that before treatment,and the difference was statistically significant(P < 0.05).The magnitude and efficacy of blood pressure reduction in group B were better than that in group A,with statistically significant(P < 0.05).The magnitude and efficiency of blood pressure reduction in group B were not statistically significant compared with those in group C(P > 0.05).Changes in serum uric acid level and the efficacy of uric acid reduction: the serum uric acid level in group A did not decrease significantly after treatment compared with that before treatment,and the difference was not statistically significant(P>0.05).The level of serum uric acid in group B and C decreased significantly after treatment compared with that before treatment,with statistically significant(P < 0.05).The magnitude and efficiency of uric acid reduction in group B were better than those in group A,with statistically significant(P<0.05).The magnitude and efficiency of uric acid reduction in group B were not statistically significant compared with those in group C(P > 0.05).The change and curative effect of TCM syndrome score: the TCM syndrome score of each group after treatment was lower than that before treatment,with statistically significant(P < 0.05).The improvement and curative effect of TCM syndromes in group B were significantly better than those in groups A and C,with statistically significant(P <0.05).Conclusion:The self-designed transforming dampness and descending turbidity soup for the treatment of hypertension combined with hyperuricemia(phlegm-dampness and blood stasis obstruction syndrome)has a good effect of lowering uric acid and reducing blood pressure,and can imrove symptoms.Its overall effect is better than simple antihypertensive drug group and antihypertensive drug combined with uric acid drug group.(1)The self-designed transforming dampness and descending turbidity soup combined with antihypertensive drug in the treatment of hypertension complicated with hyperuricemia(phlegm-dampness and blood stasis obstruction syndrome)has the efficacy of lowering uric acid and reducing blood pressure,and the effect is better than that of the simple antihypertensive drug group,and is consistent with that of antihypertensive drug combined with uric-acid-lowering drug group.(2)The self-designed transforming dampness and descending turbidity soup combined with antihypertensive drug in the treatment of hypertension complicated with hyperuricemia(phlegm-dampness and blood stasis obstruction syndrome)can improve the symptoms,and the effect is better than that of the group of simple antihypertensive drug group and the antihypertensive drug combined with uric-acid-lowering drug group.(3)The self-designed transforming dampness and descending turbidity soup combined with antihypertensive drug in the treatment of hypertension complicated with hyperuricemia(phlegm-dampness and blood stasis obstruction syndrome)has the effect of lowering uric acid,as well as lowering blood pressure and improving symptoms,and the effect is better than that of the western medicine treatment group.