Analysis Of Risk Factors Of Developing Asthma In Young Children With Wheezing

PURPOSE:Asthma is a heterogeneous disease.It is defined by the history of respiratory symptoms such as wheeze,shortness of breath,chest tightness and cough.But as a result of young children(under 5 years old)physiological reason and expression ability is limited,they are unable to properly express the bosom as frowsty,so that age children's starting symptoms is wheezing or coughing.While wheezing or cough is a common clinical symptom of young children respiratory disease.The amount of causes of cough or wheezing is big,and the auxiliary examination is limited,making the real diagnosis causes more difficult,easy to increase the rate of missed diagnosis and misdiagnosis of asthma,missing the best time to asthma.Therefore,the risk factors of childhood asthma were studied from different perspectives,which provided theoretical basis for preventing and controlling the occurrence,development and reclassification of childhood asthma.The follow-up for young children with early wheezing,for children,for management and intervention,improve the relevant auxiliary examination,so as to understand the factors associated with the occurrence of asthma,summarize the characteristics of early recognition of young children with asthma,improve the level of diagnosis,reduce the misdiagnosis rate of children with asthma.METHODS:A prospective follow-up method was used in this study.Participants: the children who came to the pediatric respiratory clinic or ward in Shengjing Hospital of China Medical University in June 2016 were selected for their complaints and wheezing.A questionnaire survey was conducted to investigate the factors related to asthma in children.Complete blood routine and serum allergen detection for all subjects.All the children were left with nasopharyngeal aspiration specimens for PCR detection of the virus swab.The standard for the diagnosis of children's asthma in2016 is based on the unified standard established by the respiratory group of the Chinese Medical Association for the moment in 2016.The results of the investigation were recorded into the computer,and the SPSS22.0 statistical software was used to establish the database and to carry out the statistical analysis.The variables were assigned to the single cause Logistic regression analysis.RESULT:1.The relationship between the genetic allergies history and asthma:parental history of atopy(referring to one of their parents have a history of allergy)mother allergic history is a risk factor for asthma(P < 0.05),while the risk of father allergic history and two relatives of allergic asthma is not a factor(P> 0.05).(2)the relationship between atopy and asthma: the positive rate of the allergen and eosinophilia increased in asthma group than in the control group,which was a risk factor for asthma(P < 0.05).(3)comparison and analysis of pulmonary function index in two groups: the concentration of exhaled nitric oxide in children with asthma was higher than that of healthy children.It was a risk factor for asthma(P < 0.05).(4)multi-factor unconditioned logistic regression model,the results showed that FENO,parents allergy,baseline allergens was statistically significant compared with control group,is the important risk factor for incident asthma children under the age of five.CONCLUSION:Through analysis,allergen,genetic allergy,eosinophilia and exhaled nitric oxide concentration are important risk factors for asthma in young children.Early prevention and treatment of asthma in young children is of great significance for the prevention of asthma.In this paper,we studied and analyzed the risk factors of asthma in young children,so as to clarify the pathogenesis of asthma,and have certain significance for early detection of asthma,early diagnosis and treatment of asthma,avoiding the development of asthma in children and continuing to adulthood.