Analysis Of Blood Lipids And Its Influencing Factors In Children With Recent Onset Type 1 Diabetes

OBJECTIVE: To analyze the blood lipids status of 348 newly diagnosed T1 DM children and to study its influencing factors.Methods: The clinical data were collected from 348 patients with recent onset type 1diabetes from 2012.1.1 to 2017.12.31,and the differences of serum lipids between T1 DM children with 40 controls were analyzed.Children with T1 DM were divided into two groups according to their blood lipids: normal blood lipids group(n=153)and dyslipidemia group(n=195),the differences between the two groups of children were compared.According to the level of Hb A1 c,the children were divided into three groups: Hb A1 c <11.5%(n=116),11.5% ?Hb A1 c <13.5%(n=109)and Hb A1c?13.5%(n=123),the differences of blood lipids between the three groups were compared.According to the p H value,the children were divided into DKA group(n=119)and non-DKA group(n=229),the differences of blood lipids between the two groups were compared.Compare the differences of blood lipids between women(n =199)and men(n = 149).Results: 1.TC,TG,LDL,apo B and TG/HDLwere significantly higher in children with T1 DM than those in the control group,while HDL and apo A1 were significantly lower than that in the control group.The results were TC(4.29 ± 1.07 vs 3.85 ± 0.67,P<0.05),TG(1.29 ± 1.40 vs 0.82 ± 0.50,P<0.01),LDL(2.61 ± 0.91 vs 2.17 ± 0.57,P<0.01),apo B(0.93 ± 0.28 vs 0.58 ± 0.14,P<0.01),TG/HDL(1.52 ± 4.78 vs 0.76 ±0.77,P<0.01),HDL(1.20 ± 0.55 vs 1.30 ± 0.35,P<0.05),apo A1(1.17 ± 0.34 vs 1.42± 0.28,P<0.01).2.The incidence of dyslipidemia in children with T1 DM was 56.03%,Hb A1 c was significantly higher in the dyslipidemia group than that in the normal lipids group(12.93 ± 2.16 vs 12.10 ± 2.37,P<0.01),and FT4 in the dyslipidemia group was significantly lower than that in the normal lipids group(13.18 ± 2.95 vs14.21 ± 4.2,P<0.01).The incidence of DKA was 24.18% in the normal lipids group and 42.05% in the dyslipidemia group.There was a significant difference between the two groups in the incidence of DKA(P<0.01).3.The patients with larger Hb A1 c had significantly higher TC,TG,LDL,apo B and TG/HDL.The results were TC(3.96 ± 0.78 vs 4.12 ± 0.94 vs 4.75 ± 1.25,P<0.01),TG(0.91 ± 0.50 vs 1.38 ± 1.72 vs 1.56 ± 1.60,P<0.01),LDL(2.34 ± 0.72 vs2.38 ± 0.73 vs 3.05 ± 1.03,P<0.01),apo B(0.83 ± 0.24 vs 0.87 ± 0.22 vs 1.07 ± 0.31,P<0.01),TG/HDL(0.89 ± 0.77 vs 1.48 ± 2.53 vs 2.16 ± 7.62,P<0.01).4.Compared with non-DKA group,TG,apo B and TG/HDL were significantly higher,while HDL and apo A1 were significantly lower in DKA group.The results were TG(1.79 ± 1.86 vs 1.02 ± 1.00,P<0.01),apo B(1.00 ± 0.31 vs 0.89 ±0.26,P<0.01),TG/HDL(1.87 ± 2.59 vs 1.35 ± 5.59,P<0.01),HDL(1.18 ± 0.79 vs1.21 ± 0.37,P<0.01),apo A1(1.13 ± 0.41 vs 1.20 ± 0.30,P<0.01).5.Dyslipidemia rate and lipids in different gender were no difference(P>0.05).Conclusions: 1.The incidence of dyslipidemia was significantly higher in children with T1 DM than normal children.2.The higher the blood glucose level,the more severe the dyslipidemia was.3.The incidence of dyslipidemia was significantly higher in children with DKA than non-DKA.