Correlation Analysis Of Ischemic Cerebrovascular Disease And Restless Legs Syndrome

Objective: Cerebrovascular disease is one of the three principal diseases causing human to death,and has a higher fatality and disability rates.The proportion of ischemic cerebrovascular disease(ICVD)is 60% to 70%.Restless legs syndrome(RLS)is a sensory and motor disorder disease of common nervous system in clinic.A noteworthy feature of RLS is discomfort and compulsive movement of calf,this syndrome affect the patient's sleep and quality of life seriously.Nowadays,the available clinical data of RLS is still scarce,while some studies found that ICVD and RLS have many shared risk factors,such as hypertension,diabetes,dyslipidemia and so on.Therefore,there may have a potential correlation between ICVD and RLS.This study aims to investigate the correlation between ICVD and RLS,and analyze the function characteristics of related factors.Methods: Firstly,acquiring the morbidity of RLS in general population through literature review,and determining the sample size of study.Chose one hundred and seventy-two patients(average age 67.38±7.56)with ICVD and without RLS who were diagnosed by department of neurology,the affiliated hospital of Qingdao university from January 2014 to July 2014 as ICVD group,whose NIHSS score from 4 to 21.The diagnosis of ICVD accord with the fourth National Conference on the diagnosis of cerebrovascular disease academic standards,and confirm the infarction location through image examination.Chose one hundred and ninety-six healthy people(average age 66.73±5.72)who were tested by health examination center of same hospital during same time as healthy control group.With a one-year follow-up,compared morbidities between two groups and analyzed the relationship between infarct locations and RLS.The diagnosis of RLS accord with the consensus of RLS diagnosis standard made by International Restless Legs Syndrome Study Group.Analyze the relationship between infarct locations and RLS.Chose ICVD patients with RLS as RLS group,rest of ICVD patients as disease control group.Analyze related risk factors by single-factor analysis and multiple logistic regression analysis.Results: Only two subjects were diagnosed with RLS in healthy control group and the morbidity is 1.02%.Eight subjects were diagnosed with RLS in ICVD group and the morbidity is 4.65%,seven of them developed symptom within six mouths.The contrast between ICVD group and healthy control group suggested that RLS prevalence of ICVD group was significantly increased(P <0.05),relative risk 4.56,95% confidence interval 3.966~5.249.RLS prevalence of patients with basal ganglia infarction was significantly higher than other infarct locations(P <0.05).According to results of single-factor analysis,RLS group is different from disease control group significantly in sex,education,hypertension,hyperlipemia,diabetes,and glycated hemoglobin(P<0.05).Multiple logistic regression analysis show that female [odds ratio(OR)1.724,95%CI 1.043~1.811;P =0.027],education [OR 1.376,95%CI 1.057 ~ 1.746;P =0.013],and the level of glycated hemoglobin [OR 1.686,95%CI 1.031 ~ 2.057;P = 0.041] are independent risk factors result in RLS.Discussion: ICVD can significantly increase the risk of RLS.Basal ganglia infarction is an important pathogenic factor.Female,education,and the level of glycated hemoglobin are independent risk factors of RLS after ICVD.