The Effects Of Aerosol Inhalation On Respiratory Mechanical Parameters Of Different Ventilator Were Studied

Objective:The effects of aerosol inhalation on respiratory mechanical parameters of different ventilator were studied by observation of mechanical ventilation patients and in vitro simulated model of aqualung.Methods:1.The effects of aerosol inhalation on respiratory mechanical parameters of different ventilator were observed.80 patients with mechanical ventilation were selected.According to the order of the patients in the ICU,A,B,C and D were divided into four groups according to the random data table method.Group A（20cases）mechanical ventilation mode is the capacity control ventilation,the atomized drive oxygen flow is7L/min and 9L/min respectively;Group B（20cases）mechanical ventilation mode is the capacity control ventilation,the atomized drive oxygen flow is 7L/min and 9L/min respectively;Group C（20cases）mechanical ventilation mode is the pressure control ventilation,the atomized drive oxygen flow is 7L/min and 9L/min respectively;Group D（20cases）mechanical ventilation mode is the pressure control ventilation,the atomized drive oxygen flow is 7L/min and 9L/min respectively.Indication of airway peak pressure（Ppeak）,suction tidal volume（VTi）,exhalation tidal volume（VTe）,blood gas analysis and ecg monitor are monitored respectively before,before and after atomization.2.In vitro model of adult mechanical ventilation combined with atomization therapy was established（simulated hydrolungs）.the ventilator was connected with the simulated hydrolungs through the respiratory pipeline to construct the model of patients with in vitro mechanical ventilation.They were divided into volume control group and pressure control group according to ventilator ventilation mode.The volume control group was given 450ml,550ml,650ml preset tidal volume,the pressure control group was given12cmH₂O,16cmH₂O,18cmH₂O preset pressure respectively.All the above groups were given 0 L/min（only atomizing device）,5L/min,7L/min,9L/min atomization driven oxygen flow rate.The values of peak airway pressure,respiratory frequency,tidal volume,exhalation volume,simulated aqualung respiratory rate（R）and tidal volume（VT）were recorded respectively.Results:1.Effect of atomization therapy on respiratory mechanics parameters in patients with mechanical ventilation.（1）.In either group A or group B,PO₂,Ppeak and VTe were significantly increased after atomization and before and after atomization,and PO₂ was significantly higher than that before atomization after atomization of A and B.The PCO₂was significantly reduced in atomization and atomization before and after atomization,and the PCO₂ in group B was higher than that in atomization（P<0.05）.In either group C or group D,the atomization was significantly higher than that of PO₂ and VTe before and after atomization,and the VTi significantly decreased（P<0.05）,and PO₂ was significantly higher after atomization than before atomization（P<0.05）.（2）.Volume control ventilation mode in group A compared with B,the observation indexes between the two groups before and after atomization differences had no statistical significance（P>0.05）,the atomization group B than in group A,PO₂,VTe were significantly increased（P<0.05）.（3）.Compared with D in group C and D in the pressure control ventilation mode,there was no statistically significant difference between the two groups before atomization（P>0.05）.Compared with group C,PO₂ and VTe in group D were significantly increased and VTi significantly decreased（P<0.05）.After atomization,group D was significantly higher than that in group C（P>0.05）.（4）.Volume ventilation mode compared with pressure ventilation mode,both in group A and group C and group B compared with group D,pressure control in front of the atomizing VTi,higher VTe obviously,Ppeak significantly decreased（P<0.05）;Ppeak,VTi and VTe were significantly reduced in atomization,and PO₂ was increased in group A compared with group C.After atomized,VTi,VTe significantly increased,Ppeak decreased significantly,and group A was significantly higher than group C,and group B was significantly lower than group D（P<0.05）.2.In vitro model of adult mechanical ventilation combined with atomization therapy（simulated scuba）:0 L/min,5 L/min,7 L/min,9 L/min atomization driven oxygen flow,ventilator during volume control ventilation The monitored VTe and VT were increased in turn（P<0.05）.There was no significant difference in VTi between the groups（P>0.05）.The VTi and VTe monitored by the ventilator and the VT displayed by the model lung were not included except at 0 L/min.Differences,the remaining 3 groups were less than VT,VTi,VTe were greater than VT（P<0.05）;compared with 0 L/min group,the other 3groups Ppeak were significantly increased（P<0.05）.During the pressure control ventilation,the oxygen flow rate was atomized at 0 L/min,5 L/min,7 L/min,and 9 L/min.There was no significant change in VT in the model lung（P>0.05）.VTi was monitored by the ventilator.In turn,VTe increased sequentially（P<0.05）;VTi and VTe monitored by ventilator and VT showed no difference except 0 L/min.The remaining 3 groups were all less than VT,and VTe was greater than VT（P<0.05）;Compared with 0 L/min group,there was no significant difference in Ppeak among the other 3 groups（P>0.05）.In both modes of mechanical ventilation,the external atomizing drive oxygen flow had no effect on the respiratory rate.Conclusion:In the capacity control mode,the external atomizing oxygen flux will increase the tidal volume and peak airway pressure at the patient’s end;under the pressure control mode,the patient’s tidal volume and airway peak pressure will not change significantly.Regardless of the capacity control ventilation group or the pressure control ventilation group,the inhaled tidal volume and exhaled tidal volume displayed on the ventilator could not truly reflect the tidal volume obtained at the patient end.The inhaled tidal volume was less than the tidal volume at the patient’s end and the tidal volume was greater than Patient tidal volume.Mechanical ventilatory exchange of oxygen flow increases arterial oxygen tension in patients.