Clinical Characteristics And Prognosis Of Children Langerhans Cell Histiocytosis Of 160 Cases

Objective : Research and analysis the clinical characteristics and treatment of children langerhans cell histiocytosis(LCH),analysis of the therapeutic effect of LCH-III project and the prognosis of LCH,evaluate and understand the overall survival rate of LCH,and provide direction for future treatment.Methods:Collect January 2010,to December 31,2016 in affiliated Children's Hospital of Chongqing Medical university during the period of hospitalization and the diagnosis of langerhans cellhistiocytosis of the patient's medical records,retrospective analyse their clinical characteristics,classification,the group and therapy.Results: There were 160 patients,male(n=89,55.6%),female(n=71,44.4%),(the ratio of male to female was 1.25:1).The median age of diagnosis was 27 months,MS-LCH(n=86,53.75%),SS-LCH(n=74,46.25%).The mass is the most common complaint symptoms(n=67),followed by fever(n= 40).81.3%(n=130)was treated with the LCH-III regimen,and 52.3%(68/130)of the patients who achieved better responsewere evaluated at 6 weeks of initial treatment.The survival analysis showed that the overall survival rate in the MS-LCH-(RO+)group was77.6%±5.3,MS-LCH-(RO-)group and SS-LCH group was 100%.A total of 24 cases(15%)had recurrence(16 cases of MS-LCH and 8 cases of SS-LCH).The most common sequelae were diabetes insipidus(n=20,12.5%).Conclusion: The clinical characteristics of LCH are various.MS-LCH is still mainly treated with systemic chemotherapy.The initial response rate of the patient is 6 weeks and the response rate is lower.The overall survival rate of SS-LCH is similar to that of an international multicenter research.The recurrence rate of patients with multiple system diseases is lower than reported in the literature.consistent with the literature.